| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
We carried out literature searching on the folding kinetics of globular proteins, and constructed a protein-folding database. The total entry number of the database is 141, consisting of 59 non-two-state proteins and 82 two-state proteins. We took the non-two-state proteins and the two-state proteins separately from the database, and investigated correlations between the logarithmic rate constant (ln kf) of folding and the structural properties of proteins. We show that using the logarithmic number of nonlocal contact clusters, a structural property proposed by us, we can clearly describe differences in the molecular mechanisms of folding between the non-two-state and the two-state proteins.
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