Investigation of membrane trafficking for HCV biogenesis
| Project/Area Number |
25440077
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
Itoh Takashi 大阪大学, 歯学研究科(研究院), 助教 (50373270)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | オートファジー / LC3結合タンパク質 / 基質認識 / Rab33B / HCV / Atg16L1 / 膜輸送 |
|---|
| Outline of Final Research Achievements |
Autophagy is a degradation system required for keeping intracellular homeostasis, eliminating insoluble protein aggregates and damaged organelle. Since excess and insufficient activity of autophagy lead to defect of the homeostasis, the regulation of autophagic activity is important. In addition, the proper recognition of substrates for degradation is also essential for maintaining the homeostasis. Here, I showed that the same molecule is used in the regulation of activity and the recognition of substrates but the way of usage is different each other.
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Report
(4 results)
Research Products
(2 results)
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[Journal Article] Differing susceptibility to autophagic degradation activity of two LC3-binding proteins: SQSTM1/p62 and TBC1D25/OATL1.2016
Author(s)
Hirano, S., Uemura, T., Annoh, H., Fujita, N., Waguri, S., Itoh, T. and Fukuda, M.
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Journal Title
Autophagy
Volume: 12
Issue: 2
Pages: 312-326
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
