Investigation of membrane trafficking for HCV biogenesis

Research Project

Project/Area Number	25440077
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Cell biology
Research Institution	Osaka University
Principal Investigator	Itoh Takashi 大阪大学, 歯学研究科(研究院), 助教 (50373270)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000) Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords	オートファジー / LC3結合タンパク質 / 基質認識 / Rab33B / HCV / Atg16L1 / 膜輸送
Outline of Final Research Achievements	Autophagy is a degradation system required for keeping intracellular homeostasis, eliminating insoluble protein aggregates and damaged organelle. Since excess and insufficient activity of autophagy lead to defect of the homeostasis, the regulation of autophagic activity is important. In addition, the proper recognition of substrates for degradation is also essential for maintaining the homeostasis. Here, I showed that the same molecule is used in the regulation of activity and the recognition of substrates but the way of usage is different each other.