| Project/Area Number |
25440115
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kitasato University (2014-2015)
Tokyo University of Science (2013) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUJI Takashi 理化学研究所, 多細胞システム形成研究センター, チームリーダー (50339131)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 運命決定 / 器官発生 / 毛包 / 毛乳頭 / 毛包幹細胞 / 毛種 |
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| Outline of Final Research Achievements |
The hair follicles, which produce various types of hair shaft in the hair bulb through the epithelial-mesenchymal interaction, are structurally and functionally associated into an integumentary organ system, composed of skin and various ectodermal mini-organs. It is well known that the organ-inductive epithelial and mesenchymal stem cells provide a source of differentiated hair follicle cells that enable hair cycling to occur over the lifetime of a mammal. We have demonstrated fully functional hair organ regeneration via the intracutaneous transplantation of a bioengineered hair follicle germ, which was reconstituted with adult epithelial and mesenchymal stem using by organ germ method. In this study, we demonstrate that the dermal papilla cells determine the hair types, which have macroscopic and microscopic features and hair type specific hair cycling patterns.
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