Background mechanism of Hepatocyte Growth Factor and Atherosclerosis in relation to Environmental Factors.

• Project/Area Number: 25440255
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied anthropology
• Research Institution: Nagasaki University
• Principal Investigator: NAKAZATO Mio 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (00380973)
• Co-Investigator(Kenkyū-buntansha): SHIMIUZU Yuji 長崎大学, 医歯薬学総合研究科(医学系), 講師 (40569068)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2015: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 肝細胞増殖因子 / 高血圧 / 動脈硬化 / ヒト肝細胞増殖因子 / ヘモグロビン / 骨髄 / 頚動脈内中膜複合体厚 / 心臓足首血管指数 / 離島 / 生活習慣 / 頸動脈内中膜複合体厚

Outline of Final Research Achievements

We measured the values of hepatocyte growth factor (HGF) in 1486 subjects who were undertaking a general health check-up. To evaluate the activity of bone marrow we focused on hemoglobin values and found that hemoglobin is significantly positively associated with hypertension and atherosclerosis. Since HGF is reported to be act as a potential index of severity of hypertension, we investigated the correlation between HGF and hemoglobin. The result of our present study showed that for both men and women hemoglobin is significantly positively correlated with HGF among hypertensive subjects but not among non-hypertensive subjects. Those results support hemoglobin as an efficient tool to evaluate vascular damage induced by hypertension in daily medical practice because hemoglobin can easily be measured.

Research Products

• [Journal Article] Hemoglobin as a possible biochemical index of hypertension-induced vascular damage (2016)
  • Author(s): Yuji Shimizu, Koichiro Kadota, Mio Nakazato, Yuko Noguchi, Jun Koyamatsu, Hirotomo Yamanashi, Mako Nagayoshi, Shuichi Nagata, Kazuhiko Arima, Takahiro Maeda.
  • Journal Title: Journal of Physiological Anthropology Volume: 35 Issue: 1 Pages: 1-7
  • DOI: 10.1186/s40101-016-0085-7
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Hemoglobin as a response marker of endothelial cell damage in non-overweight non-anemic subjects (2016)
  • Author(s): Kadota K, Shimizu Y, Nakazato M, Noguchi Y, Koyamatsu J, Yamanashi H, Nagayoshi M, Murase K, Arima K, Maeda T.
  • Journal Title: Acta Medica Nagasakiensia Volume: -
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Positive association between CD34-positive cells and urinary sodium excretion in elderly Japanese: The Nagasaki islands Study. (2014)
  • Author(s): Shimizu Y, Sato S, Koyamatsu J, Yamasaki H, Tamai M, Kadota K, Arima K, Yamasaki H, Takamura N, Maeda T
  • Journal Title: J Gerontol Geriat Res Volume: 3 Issue: 02
  • DOI: 10.4172/2167-7182.1000145
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 高血圧の影響を考慮したヘモグロビンと肝細胞増殖因子(HGF)の関係 (2016)
  • Author(s): 清水悠路、永吉真子、門田耕一郎、佐藤晋平、小屋松 淳、山梨啓友、前田隆浩
  • Organizer: 第26回日本疫学会学術総会
  • Place of Presentation: 米子コンベンションセンター(鳥取)
  • Year and Date: 2016-01-21