Polyphenols with higher molecular weights as antitumor substances in botanical foods and crude drugs

• Project/Area Number: 25450170
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Food science
• Research Institution: Okayama University
• Principal Investigator: Hatano Tsutomu 岡山大学, 医歯(薬)学総合研究科, 教授 (50127578)
• Co-Investigator(Kenkyū-buntansha): TAKEUCHI Yasuo 岡山大学, 大学院医歯薬学総合研究科, 教授 (00163387) ; SAKAGAMI Hiroshi 明海大学, 歯学部, 教授 (50138484)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ポリフェノール / タンニン / 加水分解性タンニンオリゴマー / ギョリュウ科 / Tamarix nilotica / Tamarix aphylla / Tamarix tetrandra / 抗腫瘍効果 / 食用植物 / 薬用植物 / 高分子ポリフェノール / 人工タンニン / 抗腫瘍作用 / フトモモ科 / Feijoa sellowiana / 組織培養

Outline of Final Research Achievements

Investigation of polyphenols with high-molecule structures isolated from plant organs and cultured shoots of Tamarix species of the family Tamaricaceae led to the isolation and structure elucidation of several new tannins. Antitumor effects of tannins and related polyphenols obtained from plants including those of Tamaricaceae, Myrtaceae, Davidiaceae, and Hamamelidaceae were examined, and several ones among them showed selective cytotoxic effects. Synthetic methods of tannin mimics were also established.

Research Products

• [Int'l Joint Research] Faculty of Pharmacy, Al-Azhar University(エジプト)
• [Journal Article] Hydrolyzable tannins of tamaricaceous plants. 7 Structures and cytotoxic properties of oligomeric ellagitannins from leaves of Tamarix nilotica and cultured tissues of Tamarix tetrandra (2016)
  • Author(s): Orabi MA, Taniguchi S, Sakagami H, Yoshimura M, Amakura Y, Hatano T
  • Journal Title: Journal of Natural Products Volume: 79 Issue: 4 Pages: 984-995
  • DOI: 10.1021/acs.jnatprod.5b01065
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Ellagitannins, gallotannins, and gallo-ellagitannins from the galls of Tamarix aphylla (2015)
  • Author(s): Orabi MA, Yoshimura M, Amakura Y, Hatano T
  • Journal Title: Fitoterapia Volume: 104 Pages: 55-63
  • DOI: 10.1016/j.fitote.2015.05.008
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Presentation] 未利用植物資源由来タンニンの化学構造と生物活性 (2015)
  • Author(s): 加藤沙友里，山﨑真菜，下津祐樹，青山弘枝，黒田照夫，坂上 宏，波多野 力
  • Organizer: 第6回食品薬学シンポジウム
  • Place of Presentation: 岡山市
  • Year and Date: 2015-10-30
• [Presentation] Chemistry, cytotoxicity, and in vitro production of hydrolyzable tannins of Tamarix species (2015)
  • Author(s): Orabi MA，谷口抄子，坂上 宏，、好村守生，天倉吉章，波多野 力
  • Organizer: 第6回食品薬学シンポジウム
  • Place of Presentation: 岡山市
  • Year and Date: 2015-10-30
• [Presentation] ハンカチノキの成分（第2報） (2015)
  • Author(s): 木村優里子, 青山弘枝, 下津祐樹, 坂上 宏, 波多野 力
  • Organizer: 日本生薬学会第62回年会
  • Place of Presentation: 岐阜市
  • Year and Date: 2015-09-11
• [Presentation] ハンカチノキの成分（第一報） (2015)
  • Author(s): 木村優里子、青山弘枝、 下津祐樹、黒田照夫、坂上宏、波多野力
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] 抗菌作用及び抗腫瘍作用を有するタンニン類縁体の合成 (2015)
  • Author(s): 西岡弘美、渡邉聡子、小川卓也、黒田照夫、坂上 宏、波多野力、竹内靖雄
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸市
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] Hamamelis x intermedia の抗菌作用成分の研究 (2014)
  • Author(s): 加藤沙友里、青山弘枝、黒田照夫、波多野力
  • Organizer: 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] ウヤクLindera strychnifoliaの抗菌作用成分の研究 (2014)
  • Author(s): 山崎真菜、青山弘枝、黒田照夫、波多野力
  • Organizer: 第53回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
  • Place of Presentation: 広島国際会議場
  • Year and Date: 2014-11-08 – 2014-11-09
• [Presentation] Phenolic constituents of Feijoa sellowiana (2014)
  • Author(s): Aoyama H, Kuroda T, Sakagami H, Hatano T
  • Organizer: 27th International Conference on Polyphenols
  • Place of Presentation: Nagoya University
  • Year and Date: 2014-09-02 – 2014-09-06
• [Presentation] フェイジョアFeijoa sellowiana Bergの成分研究 第３報 緑膿菌に対する作用物質 (2014)
  • Author(s): 青山弘枝、黒田照夫、波多野 力
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学（熊本県熊本市）
• [Presentation] Feijoa sellowiana の成分研究（第 2 報） (2013)
  • Author(s): 青山弘枝、黒田照夫、波多野 力
  • Organizer: 日本生薬学会第60回年会
  • Place of Presentation: 北海道医療大学（北海道当別町）
• [Book] ポリフェノール（仮題）（波多野 力、下田博司編） (2016)
  • Author(s): 波多野 力
  • Publisher: シーエムシー出版