Polyphenols with higher molecular weights as antitumor substances in botanical foods and crude drugs
| Project/Area Number |
25450170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Okayama University |
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Principal Investigator |
Hatano Tsutomu 岡山大学, 医歯(薬)学総合研究科, 教授 (50127578)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Yasuo 岡山大学, 大学院医歯薬学総合研究科, 教授 (00163387)
SAKAGAMI Hiroshi 明海大学, 歯学部, 教授 (50138484)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | ポリフェノール / タンニン / 加水分解性タンニンオリゴマー / ギョリュウ科 / Tamarix nilotica / Tamarix aphylla / Tamarix tetrandra / 抗腫瘍効果 / 食用植物 / 薬用植物 / 高分子ポリフェノール / 人工タンニン / 抗腫瘍作用 / フトモモ科 / Feijoa sellowiana / 組織培養 |
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| Outline of Final Research Achievements |
Investigation of polyphenols with high-molecule structures isolated from plant organs and cultured shoots of Tamarix species of the family Tamaricaceae led to the isolation and structure elucidation of several new tannins. Antitumor effects of tannins and related polyphenols obtained from plants including those of Tamaricaceae, Myrtaceae, Davidiaceae, and Hamamelidaceae were examined, and several ones among them showed selective cytotoxic effects. Synthetic methods of tannin mimics were also established.
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Report
(4 results)
Research Products
(14 results)
