The role of androgen in a diet-dependent development of obesity and diabetes
Project/Area Number |
25450176
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
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Research Institution | Osaka Prefecture University |
Principal Investigator |
Harada Naoki 大阪府立大学, 生命環境科学研究科(系), 講師 (00529141)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | アンドロゲン / テストステロン / 男性ホルモン / 肥満・糖尿病 / 腸内細菌 / 脂質代謝 / 糖代謝 / 大腿筋 / 肥満 / 脂肪肝 / 高脂肪食 / 去勢 / 糖尿病 |
Outline of Final Research Achievements |
In this study, we have identified an association between a high-fat diet and hypogonadism that impacts the development of obesity and fasting blood glucose levels in a castrated mouse model. The weight gain per food intake of castrated mice increased and dried fecal weight per food intake decreased in a high-fat diet-dependent manner. Fecal Firmicutes/Bacteroidetes ratio and Lactobacillus species counts increased in a high-fat diet-fed castrated mice. Antibiotic treatment did not induce obesity and high fasting blood glucose levels in castrated mice fed a high-fat diet. These results suggest that changes in gut microbiota are involved in the development of obesity triggered by hypogonadism.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Androgen Receptor Silences Thioredoxin-interacting Protein and Competitively Inhibits Glucocorticoid Receptor-Mediated Apoptosis in Pancreatic β-Cells.2015
Author(s)
Harada N, Katsuki T, Takahashi Y, Masuda T, Yoshinaga M, Adachi T, Izawa T, Kuwamura M, Nakano Y, Yamaji R, Inui H.
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Journal Title
J Cell Biochem.
Volume: 116
Issue: 6
Pages: 998-1006
DOI
Related Report
Peer Reviewed / Open Access
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