| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Numerous epidemiologic studies suggest that type 2 diabetes significantly increases cancer risk. Amadori-glycated phosphatidylethanolamine (Amadori-PE) plays a key role in the development of diabetic complications. We hypothesized that Amadori-PE may participate not only in the pathogenesis of diabetic complications but also in tumor progression. In the present study, this hypothesis was investigated in cell-culture study, with particular emphasis on the effect of Amadori-PE on telomerase activity which contributes to the infinite replicative potential of cancer cells. Amadori-PE activated MAPK pathway by inducing oxidative stress, leading to up-regulation of c-Myc and hTERT expressions, thereby increasing cellular telomerase activity. Telomerase activity was decreased by a combination treatment of Amadori-PE and alpha-tocopherol, an antioxidant vitamin. These results provide experimental evidence for a novel role of lipid glycation in linking diabetes and cancer.
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