Up-regulation of cellular telomerase activity by Amadori-glycated phosphatidylethanolamine: a link between diabetes and cancer
Project/Area Number |
25450185
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
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Research Institution | Nigata University of Phermacy and Applied Life Sciences |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 糖尿病 / 癌 / テロメラーゼ / 糖化脂質 |
Outline of Final Research Achievements |
Numerous epidemiologic studies suggest that type 2 diabetes significantly increases cancer risk. Amadori-glycated phosphatidylethanolamine (Amadori-PE) plays a key role in the development of diabetic complications. We hypothesized that Amadori-PE may participate not only in the pathogenesis of diabetic complications but also in tumor progression. In the present study, this hypothesis was investigated in cell-culture study, with particular emphasis on the effect of Amadori-PE on telomerase activity which contributes to the infinite replicative potential of cancer cells. Amadori-PE activated MAPK pathway by inducing oxidative stress, leading to up-regulation of c-Myc and hTERT expressions, thereby increasing cellular telomerase activity. Telomerase activity was decreased by a combination treatment of Amadori-PE and alpha-tocopherol, an antioxidant vitamin. These results provide experimental evidence for a novel role of lipid glycation in linking diabetes and cancer.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Establishment of an immortalized cell line derived from the prairie vole via lentivirus-mediated transduction of mutant cyclin-dependent kinase 4, cyclin D, and telomerase reverse transcriptase2016
Author(s)
Katayama M, Kiyono T, Horie K, Hirayama T, Eitsuka T, Kuroda K, Donai K, Hidema S, Nishimori K and Fukuda T
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Journal Title
Experimental Animals
Volume: 65
Issue: 1
Pages: 87-96
DOI
NAID
ISSN
0007-5124, 1341-1357, 1881-7122
Related Report
Peer Reviewed / Open Access
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