Suppression of IgE production by hydrolyzable tannins and elucidation of the mechanisms and structure-activity relationship
Project/Area Number |
25450191
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
|
Research Institution | Kyushu Sangyo University |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
山田 耕路 崇城大学, 生物生命学部, 教授 (60158186)
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | アレルギー / 加水分解性タンニン / IgE / タンニン |
Outline of Final Research Achievements |
Effects of hydrolyzable tannins on IgE production were examined. Tellimagrandin I, Tellimagrandin II, Casarictin, and Pentagalloylglucose suppressed IgE production in a dose-dependent manner. In contrast, Strictinin had little effect on IgE production. These results suggest that four golloyl groups or equivalent are needed to exert IgE suppressive effect and hydrolyzable tannins may mitigate allergic symptoms by suppression of IgE production.
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Report
(5 results)
Research Products
(1 results)