| Project/Area Number |
25450197
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Osaka Municipal Technical Research Institute |
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Principal Investigator |
Watanabe Yomi 地方独立行政法人大阪市立工業研究所, 生物・生活材料研究部, 研究主任 (60416310)
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| Co-Investigator(Kenkyū-buntansha) |
室田 佳恵子 近畿大学, 理工学部, 准教授 (40294681)
佐藤 博文 地方独立行政法人大阪市立工業研究所, 生物・生活材料研究部, 研究員 (70443546)
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| Research Collaborator |
KAZE Naoki 植田製油株式会社
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | モノクロロプロパンジオール / MCPD / グリシドール / 吸収性 / 毒性 / Caco2 / V76 / 膵リパーゼ / 小腸吸収性 / Caco-2 / エポキシド |
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| Outline of Final Research Achievements |
2- monochrolopropane diol (MCPD), the isomer of 3-MCPD, and their fatty acyl esters were synthesized and their first stage behavior after the intake were estimated in vitro. MCPD esters were estimated to be hydrolyzed to free form by pancreatic lipase and by enzymes secreted by the small intestine, and to be absorbed non-selectively and passively. Little difference was observed in the intestinal absorption btw the 2- and 3-MCPD isomers. Absorption in MCPD ester form was not observed in vitro.
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