In vitro behaviour of risky compound in oil and foods
Project/Area Number |
25450197
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Food science
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Research Institution | Osaka Municipal Technical Research Institute |
Principal Investigator |
Watanabe Yomi 地方独立行政法人大阪市立工業研究所, 生物・生活材料研究部, 研究主任 (60416310)
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Co-Investigator(Kenkyū-buntansha) |
室田 佳恵子 近畿大学, 理工学部, 准教授 (40294681)
佐藤 博文 地方独立行政法人大阪市立工業研究所, 生物・生活材料研究部, 研究員 (70443546)
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Research Collaborator |
KAZE Naoki 植田製油株式会社
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | モノクロロプロパンジオール / MCPD / グリシドール / 吸収性 / 毒性 / Caco2 / V76 / 膵リパーゼ / 小腸吸収性 / Caco-2 / エポキシド |
Outline of Final Research Achievements |
2- monochrolopropane diol (MCPD), the isomer of 3-MCPD, and their fatty acyl esters were synthesized and their first stage behavior after the intake were estimated in vitro. MCPD esters were estimated to be hydrolyzed to free form by pancreatic lipase and by enzymes secreted by the small intestine, and to be absorbed non-selectively and passively. Little difference was observed in the intestinal absorption btw the 2- and 3-MCPD isomers. Absorption in MCPD ester form was not observed in vitro.
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Report
(5 results)
Research Products
(32 results)
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[Journal Article] The collaborative study on the enzymatic analysis of positional distribution of short- and medium chain fatty acids in milk fat using immobilized Candida antarctica lipase B2016
Author(s)
K. Yoshinaga, S. Sato, R. Sasaki, M. Asada, R. Hori, J. Imagi, Y. Miyazaki, T. Nagai, K. Saito, T. Sano, A. Sasaki, C. Sato, Y. Tsukahara, A. Yamashita, S. Watanabe, Yomi Watanabe
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Journal Title
J Oleo Science
Volume: 65
Pages: 291-302
NAID
Related Report
Peer Reviewed
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[Journal Article] Collaborative study of an indirect enzymatic method for the simultaneous analysis of 3-MCPD, 2-MCPD and glycidyl esters in edible oils2016
Author(s)
K. Koyama, K. Miyazaki, K. Abe, Y. Egawa, H. Kido, T. Kitta, T. Miyashita, T. Nezu, H. Nohara, T. Sano, Y. Takahashi, H. Taniguchi, H. Yada, K. Yamazaki, Y. Watanabe
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Journal Title
J Oleo Science
Volume: 65
Pages: 557-568
NAID
Related Report
Peer Reviewed
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[Journal Article] Regiospecific Distribution of <i>trans</i>-Octadecenoic Acid Positional Isomers in Triacylglycerols of Partially Hydrogenated Vegetable Oil and Ruminant Fat2015
Author(s)
Kazuaki Yoshinaga, Yoshinori Kawamura, Takashi Kitayama, Toshiharu Nagai, Hoyo Mizobe, Koichi Kojima, Yomi Watanabe, Shinichi Sato, Fumiaki Beppu, Naohiro Gotoh
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Journal Title
Journal of Oleo Science
Volume: 64
Issue: 6
Pages: 617-624
DOI
NAID
ISSN
1345-8957, 1347-3352
Related Report
Peer Reviewed / Open Access
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[Journal Article] Enzymatic analysis of positional fatty acid distributions in triacylglycerols by 1(3)-selective transesterification with Candida antarctica lipase B: a collaborative study2015
Author(s)
Yomi Watanabe, Shinichi Sato, Mihoko Asada, Toshiharu Arishima, Yasuhiro Iida, Jun Imagi, Katsuyoshi Saito, Takashi Sano, Akiko Sasaki, Ryo Sasaki, Chiemi Sato, Tadahisa Shibuya, Yuki Tsukahara,Toshiharu Nagai,Toru Fukazawa, Ryuji Hori, Rika Homma, Yosuke Miyazaki, Atsushi Yamashita, Kazuaki Yoshinaga, Shimpei Watanabe
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Journal Title
J. Oleo Sci
Volume: 64
Pages: 1193-1205
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Applicability of a novel enzymatic method to the analysis of positional FA distribution in milk fat2015
Author(s)
○Yomi Watanabe, Ryuji Hori, Yosuke Miyazaki, Toshiharu Nagai, Katsuyoshi Saito, Takashi Sano, Akiko Sasaki, Ryo Sasaki, Shinichi Sato, Chiemi Sato, Tadahisa Shibuya, Yuki Tsukahara, Atsushi Yamashita, Kazuaki Yoshinaga, Shimpei Watanabe, Rika Homma, Jun Imagi, Mihoko Asada
Organizer
106th AOCS Annual Meeting and Industry Showcases
Place of Presentation
Orlando, USA
Year and Date
2015-05-05
Related Report
Int'l Joint Research
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[Presentation] Analysis of positional distribution of fatty acid in milk fat using a novel enzymatic method2014
Author(s)
Yomi Watanabe, Mihoko Asada, Jun Imagi, Katsuyoshi Saito, Akiko Sasaki, Ryo Sasaki, Shinichi Sato, Chiemi Sato, Takashi Sano, Tadahisa Shibuya, Toshiharu Nagai, Yuki Tsukahara, Ryuji Hori, Rika Homma, Yosuke Miyazaki, Atsushi Yamashita, Kazuaki Yoshinaga, Shimpei Watanabe
Organizer
Active Enzyme Molecule 2014
Place of Presentation
富山国際会議場(富山県富山市)
Year and Date
2014-12-18 – 2014-12-19
Related Report
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