Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Outline of Final Research Achievements |
To identify the region of bovine lactoferrin that is responsible for suppression of tumor-induced angiogenesis, we compared the effect of lactoferrin fragments on VEGF-induced angiogenesis. C-lobe fragment of bovine lactoferrin was more potent inhibitor for angiogenesis. Bovine lactoferrin interacted with CXCR4-containing lipoparticle. Lactoferrin stimulation mimicked many aspects of SDF-1-induced CXCR4 modification, including receptor dimerization, tyrosine phosphorylation, and ubiquitination, suggesting that CXCR4 acts as a lactoferrin receptor.
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