Elucidation of inhibitory mechanisms of bovine lactoferrin for tumor-induced angiogenesis.
Project/Area Number |
25450413
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Animal production science
|
Research Institution | National Agriculture and Food Research Organization |
Principal Investigator |
Yoshiharu Takayama 国立研究開発法人農業・食品産業技術総合研究機構, 畜産研究部門 畜産物研究領域, 上級研究員 (00343989)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | タンパク質 / 農林水産物 / 細胞・組織 / 受容体 / ラクトフェリン / 蛋白質 / シグナル伝達 / 血管新生 |
Outline of Final Research Achievements |
To identify the region of bovine lactoferrin that is responsible for suppression of tumor-induced angiogenesis, we compared the effect of lactoferrin fragments on VEGF-induced angiogenesis. C-lobe fragment of bovine lactoferrin was more potent inhibitor for angiogenesis. Bovine lactoferrin interacted with CXCR4-containing lipoparticle. Lactoferrin stimulation mimicked many aspects of SDF-1-induced CXCR4 modification, including receptor dimerization, tyrosine phosphorylation, and ubiquitination, suggesting that CXCR4 acts as a lactoferrin receptor.
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Report
(4 results)
Research Products
(11 results)