| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Outline of Final Research Achievements |
The mice inoculated with a lethal dose of okadaic acid, a dirrhetic shellfish poisoning toxin, showed the accumulation of the fluid in the intestine within a few hours after inoculation. The fluid in the intestine is thought to be plasma from the blood. The decrease of blood volume and the circulatory failure might lead to tissue damage and multi organ dysfunction, and finally death. The decrease of the body temperature could be a new, useful, rapid and humane index for judging the results of the mouse bioassay for dirrhetic shellfish poisoning toxins, instead of the present index, the death of the animals.
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