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Establishment of the bone marrow stromal cell autotransplantation therapy for the chronic liver in dogs

Research Project

Project/Area Number 25450443
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Veterinary medical science
Research InstitutionYamaguchi University

Principal Investigator

TANI KENJI  山口大学, 共同獣医学部, 准教授 (00365420)

Co-Investigator(Kenkyū-buntansha) TAURA YASUHO  山口大学, 共同獣医学部, 教授 (80163153)
YAMAMOTO NAOKI  山口大学, 大学教育機構, 講師 (90448283)
仲澤 宏  山口大学, 共同獣医学部, 助教 (90604992)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords骨髄間質細胞 / 再生医療 / 慢性肝炎 / 肝線維症 / 肝動脈 / 犬 / ICGクリアランス / 肝機能検査 / 移植
Outline of Final Research Achievements

Auto-transplantation therapy was evaluated for dogs with liver injured induced with carbon tetrachloride (CCl4) by using cryopreserved bone marrow stromal cells (BMSCs). The statistical significant difference was not found in various parameters in treated dogs, however, interestingly, BMSC effect was found in dogs with severe liver injury. A hepatic fibrosis region reduced when BMSC treatment was performed via transcatheter hepatic artery. Canine BMSC may be a source cell to improve liver injury and hepatic artery course may raise the effect of the treatment.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2015 2014

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Anatomical evaluation of hepatic vascular system in healthy beagles using X-ray contrast computed tomography2015

    • Author(s)
      Yasuhisa OISHI, Kenji TANI,, Hiroshi NAKAZAWA, Kazuhito ITAMOTO, Tomoya HARAGUCHI, and Yasuho TAURA
    • Journal Title

      Journal of Veterinary Medical Science

      Volume: 77 Issue: 8 Pages: 925-929

    • DOI

      10.1292/jvms.14-0469

    • NAID

      130005094666

    • ISSN
      0916-7250, 1347-7439
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Anatomical evaluation of hepatic vascular system in healthy beagles using X-ray contrast computed tomography2015

    • Author(s)
      Oishi Y, Tani K, Nakazawa H, Itamoto K, Haraguchi T, Taura Y.
    • Journal Title

      J Vet Med Sci

      Volume: -

    • NAID

      130005094666

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Effect of arterial embolization in four dogs with hepatocellular carcinoma2015

    • Author(s)
      Oishi. Y, Tani. K, Itamoto. K, Haraguchi. T, Taura. Y
    • Organizer
      The 5th Annual Congress of Asian Society of Veterinary Surgery.
    • Place of Presentation
      Kuala Lumpur, Malaysia
    • Year and Date
      2015-11-01
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ANATOMICAL EVALUATION OF HEPATIC VASCULAR SYSTEM USING X-RAY CONTRASTING COMPUTED TOMOGRAPHY IN HEALTHY BEAGLE DOGS2014

    • Author(s)
      Yasuhisa Oishi, Kenji Tani, Hiroshi Nakazawa, Kazuhito Itamoto, Tomoya Haraguchi, Yasuho Taura
    • Organizer
      The 4th Annual Congress of Asian Society of Veterinary Surgery
    • Place of Presentation
      大阪国際交流センター、大阪市
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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