Establishment of the bone marrow stromal cell autotransplantation therapy for the chronic liver in dogs

2015 Fiscal Year Final Research Report

• Project/Area Number: 25450443
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Yamaguchi University
• Principal Investigator: TANI KENJI 山口大学, 共同獣医学部, 准教授 (00365420)
• Co-Investigator(Kenkyū-buntansha): TAURA YASUHO 山口大学, 共同獣医学部, 教授 (80163153) ; YAMAMOTO NAOKI 山口大学, 大学教育機構, 講師 (90448283)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Keywords: 骨髄間質細胞 / 再生医療 / 慢性肝炎 / 肝線維症 / 肝動脈 / 犬

Outline of Final Research Achievements

Auto-transplantation therapy was evaluated for dogs with liver injured induced with carbon tetrachloride (CCl4) by using cryopreserved bone marrow stromal cells (BMSCs). The statistical significant difference was not found in various parameters in treated dogs, however, interestingly, BMSC effect was found in dogs with severe liver injury. A hepatic fibrosis region reduced when BMSC treatment was performed via transcatheter hepatic artery. Canine BMSC may be a source cell to improve liver injury and hepatic artery course may raise the effect of the treatment.

Free Research Field

獣医外科学