Clinical application study on evaluating models for skin pigmentation

Research Project

Project/Area Number	25450459
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Veterinary medical science
Research Institution	Yamaguchi University (2014-2015) Okazaki Research Facilities, National Institutes of Natural Sciences (2013)
Principal Investigator	Kimura Tohru 山口大学, 共同獣医学部, 教授 (80419027)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000) Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords	メラノサイト / メラニン顆粒 / 肥厚性瘢痕 / 実験モデル / 皮膚 / 形成外科
Outline of Final Research Achievements	The author previously reported dermatological and plastic surgical research results using 2 kinds of laboratory animals (hairless dogs and Japanese monkeys). Based on the use of hairless dogs, the author established an excellent system to evaluate pigmentation after ultraviolet A (UVA) exposure and hyperpigmenting hypertrophic scar. Additionally, clinical research was done using an experiment model of dermal melanocytosis in Japanese monkeys. During the present study period, the author elucidated the following isuues: 1. evaluation of UVA-induced pigmentation model with hairless dogs, 2. evaluation of hyperpigmenting hypertrophic scar model provoked in the skin of hairless dogs and 3. Evaluation of depigmenting drugs using dermal melanocytosis in Japanese monkeys.