| Project/Area Number |
25450461
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Integrative animal science
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
WATANABE Kouichi 東北大学, (連合)農学研究科(研究院), 助教 (80261494)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
ASO Hisashi 東北大学, 大学院農学研究科, 教授 (50241625)
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 超疲労耐久性筋線維 / ウシ / ３－ヒドロキシ酪酸脱水素酵素 / カルシウムイオン関連因子 / Sirtuin / カルニチンアシル基転移酵素ー１ｂ / 機能適応 / ID型筋線維 / 骨格筋 / 筋線維型 / カルニチンアシル基転移酵素-1ｂ / 3-ヒドロキシ酪酸脱水素酵素 |
|---|
| Outline of Final Research Achievements |
Ruminant-specific type ID myofibers as a super fatigue-resistant myofiber, which are distributed in anti-gravity muscles involved in posture maintenance, possess strong 3-hydroxybutyrate dehydrogenase activity. In bovine muscles, our results suggest that type ID myofibers are possible to keep higher sarcoplasmic calcium ion level for long-term muscular movement, and have higher metabolic capacity of fatty acid than other myofiber types for sufficient energy supply. Moreover, it suggests that sirtuin1 activate PGC-1alpha for increasing of mitochondria in myofiber transition of "type IIB to type IIA" as oxidative change. Successively, upregulation of sirtuin3 in mitochondria seems to lead induction of fast-to-slow transformation and appearance of type ID myofiber involved in super fatigue-resistance.
|
