Analysis of mechanism of gene expression regulation by testis-specific homeodomain protein
| Project/Area Number |
25450465
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Kagoshima University (2015)
Tottori University (2013-2014) |
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Principal Investigator |
ASANO Atsushi 鹿児島大学, 農水産獣医学域獣医学系, 教授 (90312404)
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| Co-Investigator(Kenkyū-buntansha) |
YAMANO Yoshiaki 鳥取大学, 農学部, 教授 (00182593)
TAKEUCHI Takashi 鳥取大学, 農学部, 教授 (10325061)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 精子形成 / ホメオドメインタンパク質 / 転写調節 |
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| Outline of Final Research Achievements |
To clarify the role of transcription factors in the control of gene expression in spermatogenesis, we analyzed expression and function of a homeodomain protein, Nkx2-6, that was estimated to be a testis-specific expressed protein. We found that Nkx2-6 was mainly expressed in testis, and that spermatids highly expressed this protein. In addition, we found that Nkx2-6 had potential as a gene-expression regulator of testis-specific genes, Prm1 and Akap3. In this study, we show part of the function of Nkx2-6 in regulation gene expression associated with spermatogenesis.
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Report
(4 results)
Research Products
(1 results)
