Cytoskeleton synthesis is involved in the signaling from vesicle transport to ribosome synthesis
| Project/Area Number |
25450516
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied molecular and cellular biology
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| Research Institution | Hiroshima University |
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Principal Investigator |
Mizuta Keiko 広島大学, 生物圏科学研究科, 名誉教授 (40166012)
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| Co-Investigator(Kenkyū-buntansha) |
FUNATO KOUICHI 広島大学, 大学院生物圏科学研究科, 准教授 (30379854)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | リボソーム生合成 / 小胞輸送 / 核小体 / 核膜 / 酵母 / 分泌経路 / シグナル伝達 / Rrs1 / 出芽酵母 / Arp2/3複合体 |
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| Outline of Final Research Achievements |
Secretory defects cause transcriptional repression of both ribosomal RNA and ribosomal protein genes in Saccharomyces cerevisiae. Rrs1 and Ebp2, ribosome biogenesis factors, are involved in the signaling pathway induced by secretory defects. We found that disruption of all four genes encoding GSK-3 homologs, especially Mck1, diminished the transcriptional repression of ribosomal protein genes in response to secretory defects. We showed that Rrs1 interacts with Arc35, a component of Arp2/3 complex and that Arc35 was involved in the secretory response via regulation of both actin and microtubule kinetochore.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] The essential function of Rrs1 in ribosome biogenesis is conserved in budding and fission yeasts.2015
Author(s)
Kun Wan, Haruka Kawara, Tomoyuki Yamamoto, Kazunori Kume, Yukari Yabuki, Tetsuya Goshima, Kenji Kitamura, Masaru Ueno, Muneyoshi Kanai, Dai Hirata, Kouichi Funato, Keiko Mizuta
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Journal Title
Yeast
Volume: 32
Issue: 9
Pages: 607-614
DOI
Related Report
Peer Reviewed
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[Journal Article] Sphingolipid regulate telomere clustering by affecting transcriptional levels of genes involved in telomere homeostasis.2015
Author(s)
Atsuko Ikeda, Tetsuya Muneoka, Suguru Murakami, Ayaka Hirota, Yukari Yabuki, Takafumi Karashima, Kota Nakazono, Masahiro Tsuruno, Harald Pichler, Katsuhiko Shirahige, Yukiko Kodama, Toshi Shimamoto, Keiko Mizuta, Kouichi Funato
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Journal Title
J. Cell Sci.
Volume: 128
Pages: 2454-2467
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] COPII coat composition is actively regulated by luminal cargo maturation2015
Author(s)
Manzano-Lopez J, Perez-Linero AM, Aguilera-Romero A, Martin ME, Okano T, Silva DV, Seeberger PH, Riezman H, Funato K, Goder V, Wellinger RE, Muniz M.
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Journal Title
Curr. Biol.
Volume: 25
Issue: 2
Pages: 152-162
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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