Development of Synthetic Methods for Heterocycles Using Transition-Metal Catalyzed C-H Functionalization
Project/Area Number |
25460002
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Chemical pharmacy
|
Research Institution | Mukogawa Women's University (2014-2015) Tohoku University (2013) |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 触媒・化学プロセス / 有機化学 / 遷移金属 / C-H 官能基化 / 複素環化合物 / パラジウム / C-H官能基化 / 閉環反応 / キサンチン類 / C-H 官能基化 / 非対称化 / 炭素-水素結合官能基化 / ルテニウム / 一酸化炭素 / ジベンゾピラノン環 |
Outline of Final Research Achievements |
Catalytic carbonylative C-H cyclization of 2-arylphenols can be achieved in the presence of a ruthenium-based catalytic system. The process proceeds efficiently under balloon pressure of CO and produces variously substituted 6H-dibenzo[b,d]pyran-6-one compounds, typically in good to high yields. In addition, a novel synthetic procedure for the construction of the xanthine framework has been developed by using a copper catalyst. Furthermore, enantioselective C-H cyclization via desymmetrization was also examined. However, the product obtained was a mixture of racemic compounds.
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Report
(4 results)
Research Products
(28 results)
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[Journal Article] Unusual, Chemoselective Etherification of 2-Hydroxy-1,4-naphthoquinone Derivatives Utilizing Alkoxymethyl Chlorides: Scope, Mechanism and Application to the Synthesis of Biologically Active Natural Product (±)-Lantalucratin C2016
Author(s)
Tokutaro Ogata, Tomoyo Yoshida, Maki Shimizu, Manami Tanaka, Chie Fukuhara, Junko Ishii, Arisa Nishiuchi, Kiyofumi Inamoto, Tetsutaro Kimachi
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Journal Title
Tetrahedron
Volume: 72
Issue: 11
Pages: 1423-1432
DOI
Related Report
Peer Reviewed
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[Journal Article] Unusual <i>O</i>-Alkylation of 2-Hydroxy-1,4-naphthoquinone Utilizing Alkoxymethyl Chlorides2015
Author(s)
Tokutaro Ogata, Tomoyo Yoshida, Manami Tanaka, Chie Fukuhara, Maki Shimizu, Junko Ishii, Arisa Nishiuchi, Kiyofumi Inamoto, Tetsutaro Kimachi
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 63
Issue: 7
Pages: 485-488
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed
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