Formulation design of pharmaceutical emulsions based on magnetic resonance imaging and quality-by-design approach
| Project/Area Number |
25460045
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Toyama (2015)
Hoshi University (2013-2014) |
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Principal Investigator |
Onuki Yoshinori 富山大学, 大学院 医学薬学研究部(薬学), 客員教授 (10350224)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | MRI / クリーム剤 / 製剤安定性 / QbD / エマルション製剤 / 自己組織化マップ / 水分子運動性 |
|---|
| Outline of Final Research Achievements |
Physical stability is an important quality attribute of pharmaceutical emulsions. In general, the physical stability is affected by various factors in a complicated manner. Since the quality-by-design concept was issued, the importance of understanding the relationships between formulation variables and responses has been expanding in the development of pharmaceuticals. The purpose of this study is to gain a comprehensive understanding of the physical stability of pharmaceutical emulsions. The key technology used to evaluate the state of water was magnetic resonance imaging (MRI). From the findings, formulation variables had a significant impact on the state of water in the model formulations. Furthermore, it was clarified that the state of water played an important role in the stability of the model emulsions. In conclusion, we succeeded in gaining a comprehensive understanding of the physical stability of the model emulsions and establishing conditions to prepare stable emulsions.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Magnetic Resonance Imaging of the Phase Separation in Mixed Preparations of Moisturizing Cream and Steroid Ointment after Centrifugation2015
Author(s)
Onuki, Y., Funatani, C., Yokawa, T., Yamamoto, Y., Fukami, T., Koide, T., Obata, Y., Takayama, K.
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 63
Issue: 5
Pages: 377-383
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Magnetic Resonance Imaging Study on the Physical Stability of Menthol and Diphenhydramine Cream for the Treatment of Chronic Kidney Disease-Associated Pruritus2015
Author(s)
Onuki, Y., Machida, Y., Yokawa, T., Seike, C., Sakurai, S., Takayama, K.
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 63
Issue: 6
Pages: 457-462
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Self-organizing Map Analysis for Understanding Comprehensive Relationships between Formulation Variables, State of Water, and the Physical Stability of Pharmaceutical Emulsions2015
Author(s)
Onuki, Y., Hasegawa, N., Horita, A., Ueno, N., Kida, C., Hayashi, Y., Obata, Y., Takayama, K.
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 63
Issue: 11
Pages: 901-906
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed / Acknowledgement Compliant
-
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[Journal Article] Contribution of Glucose to Crystallization of Phenytoin in Injectable Dosage Form by Dilution with Infusion Fluids2014
Author(s)
Onuki, Y., Hasegawa, N., Ikegami-Kawai, M., Suematsu, T., Sakurai, S., Shirozu, S., Tsubuki, M., Obata, Y., Takayama, K.
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 62
Issue: 10
Pages: 989-993
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Effect of Process Variables on the Drucker–Prager Cap Model and Residual Stress Distribution of Tablets Estimated by the Finite Element Method2014
Author(s)
Hayashi, Y., Otoguro, S., Miura, T., Onuki, Y., Obata, Y., Takayama, K.
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Journal Title
Chemical and Pharmaceutical Bulletin
Volume: 62
Issue: 11
Pages: 1062-1072
DOI
NAID
ISSN
0009-2363, 1347-5223
Related Report
Peer Reviewed / Acknowledgement Compliant
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