| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Physical stability is an important quality attribute of pharmaceutical emulsions. In general, the physical stability is affected by various factors in a complicated manner. Since the quality-by-design concept was issued, the importance of understanding the relationships between formulation variables and responses has been expanding in the development of pharmaceuticals. The purpose of this study is to gain a comprehensive understanding of the physical stability of pharmaceutical emulsions. The key technology used to evaluate the state of water was magnetic resonance imaging (MRI). From the findings, formulation variables had a significant impact on the state of water in the model formulations. Furthermore, it was clarified that the state of water played an important role in the stability of the model emulsions. In conclusion, we succeeded in gaining a comprehensive understanding of the physical stability of the model emulsions and establishing conditions to prepare stable emulsions.
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