Roles of Neudesin in high-fat diet induced obesity
| Project/Area Number |
25460065
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Biological pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
Itoh Nobuyuki 京都大学, 薬学研究科(研究院), 名誉教授 (10110610)
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| Co-Investigator(Renkei-kenkyūsha) |
KONISHI Morichika 神戸薬科大学, 薬学部, 教授 (00322165)
OHTA Hiroya 神戸薬科大学, 薬学部, 研究員 (40638988)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 分泌性タンパク質 / マウス / 遺伝子欠損 / 肥満 / エネルギー代謝 / 遺伝子欠 |
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| Outline of Final Research Achievements |
Some neurotrophic factors have recently been implicated in the control of energy balance by increasing energy expenditure. We previously identified neudesin as a novel neurotrophic factor with potential roles in the central nervous system. Although neudesin is also expressed in various peripheral tissues including adipose tissue, its physiological roles have not yet been elucidated. We found that neudesin knockout (KO) mice were resistant to high-fat diet-induced obesity and obesity-related metabolic dysfunctions. neudesin KO mice exhibited increased energy expenditure due to increased sympathetic activity, which resulted in increased heat production and fatty acid oxidation in brown adipose tissue and enhanced lipolysis in white adipose tissue. Thus, neudesin, which may be a negative regulator of sympathetic activity, could represent a novel regulator of the development of obesity and obesity-related metabolic dysfunctions.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Deletion of Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity2015
Author(s)
Hiroya Ohta, Morichika Konishi, Yusuke Kobayashi, Atsuki Kashio, Takayuki Mochiyama, Shigenobu Matsumura, Kazuo Inoue, Tohru Fushiki, Kazuwa Nakao, Ikuo Kimura, Nobuyuki Itoh
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Journal Title
Scientific Reports
Volume: 印刷中
Issue: 1
Pages: 10049-10049
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Deletion of the Neurotrophic Factor neudesin Prevents Diet-induced Obesity by Increased Sympathetic Activity2015
Author(s)
H. Ohta, M. Konishi, Y. Kobayashi, A. Kashio, T. Mochiyama, S. Matsumura, K. Inoue, T. Fushiki, K. Nakao, I. Kimura, N. Itoh
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Journal Title
Scientific Reports
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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