| Project/Area Number |
25460099
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Osaka University |
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Principal Investigator |
AGO Yukio 大阪大学, 薬学研究科(研究院), 助教 (50403027)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUDA TOSHIO 大阪大学, 大学院薬学研究科, 教授 (00107103)
TAKUMA KAZUHIRO 大阪大学, 大学院歯学研究科, 教授 (90289025)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 精神疾患 / エンカウンター刺激 / 個体間相互作用 / 環境因子 / 覚せい剤 / 抗うつ薬 / 雌選択性試験 / 長期隔離飼育マウス / グルタミン酸神経 / 大脳皮質前頭前野 / モノアミン |
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| Outline of Final Research Achievements |
Clinical and preclinical studies suggest that psychological stress plays an important role in expression of symptoms in various types of mental illness. In this study, we have established a novel methodology for assessing social interaction as a psychological stressor, named the social encounter test. Then, we identified the primary neurochemical signal for induction of abnormal behaviors in post-weaning isolation-reared mice, a mouse model of psychiatric disorders. Using the encounter response, furthermore, we developed a new test for evaluating reward-seeking behavior or motivation in mice. These analyses would provide new insights into the pathophysiology of psychiatric disorders including schizophrenia, depression and drug dependence, and the development of therapeutic strategies for these diseases.
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