The role of the mTOR signalling pathway in placental nutrient transport.

• Project/Area Number: 25460211
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical pharmacy
• Research Institution: Health Sciences University of Hokkaido (2015); Kobe University (2013-2014)
• Principal Investigator: HIRANO TAKESHI 北海道医療大学, 薬学部, 教授 (00322826)
• Co-Investigator(Kenkyū-buntansha): HIRAI Midori 神戸大学, 医学部附属病院, 教授 (70228766)
• Co-Investigator(Renkei-kenkyūsha): YAMAMOTO Kazuhiro 神戸大学, 医学部附属病院, 薬剤師 (30610349)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 胎盤栄養素輸送 / 医療薬学 / 食品栄養学 / 医薬品情報学 / 安全性学 / mTOR / 栄養感知システム / 妊娠 / mTORC1 / Raptor / ZNF512B / p-4EBP1 / eIF4E / 4EBP1 / P110 / SNAT3 / AMPK

Outline of Final Research Achievements

The mTOR pathway represents an important intracellular regulatory process between nutrient and amino acid transport in the human placenta. PI3K and mTOR pathway, a novel p110 interacting protein was identified by the protein-protein interactions using co-immunoprecipitation. We demonstrate the p110 catalytic subunit directly binds to mTORC1. These results suggested that P110 is important factor and the mTOR regulator. We suggest that mTOR signaling represents an important regulatory pathway for placental nutrient transporters.

Research Products

• [Presentation] 新規mTORC1結合因子P110の栄養感知システムとしての生理機能解析 (2014)
  • Author(s): 七里博章、山本和宏、中川勉、平野剛、平井みどり
  • Organizer: 第37回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-11-25 – 2014-11-27