Construction of the experimental model for assessment of motivation using rat intracranial self-stimulation model
Project/Area Number |
25460212
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Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Medical pharmacy
|
Research Institution | Okayama University |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 脳内自己刺激行動 / 意欲 / Phasic firing / 抗がん剤 / Tyrosine Hydroxylase / Bromodeoxyuridine / 意欲行動 / 動機づけ / プラミペキソール |
Outline of Final Research Achievements |
In the present study, we constructed the experimental model using the intracranial self-stimulation to evaluate "motivation" and assessed the impact of drug administration on the motivation. The intracranial self-stimulation behavior is one of the experimental method for the assessment of brain reward function.As a result, it was demonstrated that brain dopamine nerves showed an important role in motivation, and that amplifying the action of dopamine which was released from the nerve terminal would be important in improving motivation. In addition, it was suggested that the brain nerve cell was possibility activated by the acquisition of motivated behavior.
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Report
(4 results)
Research Products
(3 results)