Estimation of bitterness intenisty of drug using IAsys
| Project/Area Number |
25460234
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
yoshida miyako 武庫川女子大学, 薬学部, 准教授 (20369028)
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| Co-Investigator(Kenkyū-buntansha) |
内田 享弘 武庫川女子大学, 薬学部, 教授 (70203536)
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| Co-Investigator(Renkei-kenkyūsha) |
HAZEKAW Mai 福岡大学, 薬学部, 助教 (10509186)
HARAGUCHI Tamami 武庫川女子大学, 薬学部, 助教 (10550741)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | bitterness intensity / 苦味 / 苦味受容体 / 苦味予測 / ヒト苦味受容体 |
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| Outline of Final Research Achievements |
The interaction of T2R which was a bitterness receptor of the Homo sapiens and bitter drugs was evaluated by SPRNavi . The affinity was evaluated as bitterness intensity of drug. At first, as a standard drug of the bitterness, quinine hydrochloride to use as a sample (standard sample) was used for establishment of quantative bitterness measurement condition. Correlation bitween affinity and gustatory sensation test was also evaluated. Affinity with T2R14 was suggested to be high for the high hydrophobic drug and these drugs suggested to have strong bitterness.
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Report
(5 results)
Research Products
(18 results)
