Genetic and cellular characteristics of the pre-placodal region
| Project/Area Number |
25460252
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Jichi Medical University |
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Principal Investigator |
SATO Shigeru 自治医科大学, 医学部, 准教授 (70306108)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 感覚器形成 / プラコード / 転写制御 / マウス / ニワトリ / アフリカツメガエル / 内耳 / 嗅上皮 / Cre-lox / エンハンサー / 神経堤 / 難聴 / ニワトリ胚 / トランスジェニックマウス / 遺伝子改変マウス / ホメオボックス遺伝子 / 比較ゲノム / Six1遺伝子 / 感覚器プラコード |
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| Outline of Final Research Achievements |
The aim of this study was to understand genetic and cellular characteristics of the sensory placodes and their precursor domain (PPR). 1) All materials required for the identification of Six1-target genes were prepared. 2) The PPR-specific enhancer of Xenopus Six1 was characterized. 2) Two new mouse lines expressing Cre under the control of two placode-specific Six1 enhancers were developed. 4) Cell ablation experiments were carried out using the two Cre-expressing mouse lines. The above results provided novel information on the regulation and function of Six1 and Six1-expressing cells, and should advance our understandings on the sensory organogenesis.
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Report
(4 results)
Research Products
(6 results)
