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Genetic and cellular characteristics of the pre-placodal region

Research Project

Project/Area Number 25460252
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General anatomy (including histology/embryology)
Research InstitutionJichi Medical University

Principal Investigator

SATO Shigeru  自治医科大学, 医学部, 准教授 (70306108)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords感覚器形成 / プラコード / 転写制御 / マウス / ニワトリ / アフリカツメガエル / 内耳 / 嗅上皮 / Cre-lox / エンハンサー / 神経堤 / 難聴 / ニワトリ胚 / トランスジェニックマウス / 遺伝子改変マウス / ホメオボックス遺伝子 / 比較ゲノム / Six1遺伝子 / 感覚器プラコード
Outline of Final Research Achievements

The aim of this study was to understand genetic and cellular characteristics of the sensory placodes and their precursor domain (PPR). 1) All materials required for the identification of Six1-target genes were prepared. 2) The PPR-specific enhancer of Xenopus Six1 was characterized. 2) Two new mouse lines expressing Cre under the control of two placode-specific Six1 enhancers were developed. 4) Cell ablation experiments were carried out using the two Cre-expressing mouse lines. The above results provided novel information on the regulation and function of Six1 and Six1-expressing cells, and should advance our understandings on the sensory organogenesis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report

Research Products

(6 results)

All 2015 2014 Other

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (1 results) Remarks (1 results)

  • [Journal Article] Activation of Six1 Expression in Vertebrate Sensory Neurons.2015

    • Author(s)
      Sato S*, Yajima H, Furuta Y, Ikeda K, Kawakami K.
    • Journal Title

      PloS One

      Volume: Aug 27;10(8) Pages: 1-21

    • DOI

      10.1371/journal.pone.0136666

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A Phox2b BAC Transgenic Rat Line Useful for Understanding Respiratory Rhythm Generator Neural Circuitry.2015

    • Author(s)
      Ikeda K, Takahashi M, Sato S, Igarashi H, Ishizuka T, Yawo H, Arata S, Southard-Smith EM, Kawakami K, Onimaru H.
    • Journal Title

      PloS One

      Volume: 10 Pages: 1-15

    • DOI

      10.1371/journal.pone.0132475

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Six1 is a key regulator of the developmental and evolutionary architecture of sensory neurons in craniates2014

    • Author(s)
      H. Yajima, M. Suzuki, H. Ochi, K. Ikeda, S. Sato, K. Yamamura, H. Ogino, N. Ueno and K. Kawakami
    • Journal Title

      BMC Biology

      Volume: 12 Pages: 12-40

    • DOI

      10.1186/1741-7007-12-40

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Fgfr1-Frs2/3 Signalling Maintains Sensory Progenitors during Inner Ear Hair Cell Formation.2014

    • Author(s)
      Ono K
    • Journal Title

      PLoS Genet.

      Volume: 10

    • DOI

      10.1371/journal.pgen.1004118

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Six1遺伝子の感覚神経系における役割とその発現制御2014

    • Author(s)
      佐藤 滋,矢嶋 浩,川上 潔
    • Organizer
      日本遺伝学会第86回大会
    • Place of Presentation
      長浜バイオ大学
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Research-status Report
  • [Remarks] 自治医科大学細胞生物研究部ホームページ

    • URL

      http://www.jichi.ac.jp/biol/home.html

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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