Analysis of the transcription factor crosstalk in high endothelial venule formation
| Project/Area Number |
25460268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Kinki University (2015)
Osaka University (2013-2014) |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 血管内皮細胞 / 転写因子 / リンパ節 / 分化 / 内皮細胞分化 |
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| Outline of Final Research Achievements |
The high endothelial venules (HEVs) are specialized blood vessels that permit lymphocyte trafficking across their endothelial cells (ECs) and develop in a tissue-specific manner. We previously found that a transcription factor X is preferentially expressed in immature HEV-ECs of lymph nodes and Peyer's patches. We found that neonatal HEVs in the gene X -knockout (KO) mice express lower levels of HEV-EC marker proteins than wild type littermates. In contrast, postnatal HEVs in the gene X-transgenic mice showed an increase in HEV-EC marker proteins. These results support the hypothesis that the gene X contributes to HEV-EC differentiation.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Fibroblastic reticular cell-derived lysophosphatidic acid regulates confined intranodal T-cell motility.2016
Author(s)
Takeda A, Kobayashi D, Aoi K, Sasaki N, Sugiura Y, Igarashi H, Tohya K, Inoue A, Hata E, Akahoshi N, Hayasaka H, Kikuta J, Scandella E, Ludewig B, Ishii S, Aoki J, Suematsu M, Ishii M, Takeda K, Jalkanen S, Miyasaka M, Umemoto E.
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Journal Title
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.2016
Author(s)
Hata E, Sasaki N, Takeda A, Tohya K, Umemoto E, Akahoshi N, Ishii S, Bando K, Abe T, Kano K, Aoki J, Hayasaka H, Miyasaka M
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Journal Title
Int Immunol.
Volume: なし
Issue: 6
Pages: 283-292
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Dynamic changes in endothelial cell adhesion molecule nepmucin/CD300LG expression under physiological and pathological conditions.2013
Author(s)
Umemoto, E, Takeda, A., Jin, S., Luo, Z., Nakahogi, N., Hayasaka, H., Lee, C.M., Tanaka, T. & Miyasaka, M.
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Journal Title
PLoS One
Volume: 8
Issue: 12
Pages: 1-12
DOI
Related Report
Peer Reviewed
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