| Project/Area Number |
25460283
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General physiology
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| Research Institution | Gifu University |
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Principal Investigator |
Obata Koji 岐阜大学, 医学(系)研究科(研究院), 助教 (40378229)
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| Co-Investigator(Kenkyū-buntansha) |
Takaki Miyako 奈良県立医科大学, 医学部, 研究員 (00033358)
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| Co-Investigator(Renkei-kenkyūsha) |
Nakai Junichi 埼玉大学, 理工学研究科, 教授 (80237198)
Ohkura Masamichi 埼玉大学, 理工学研究科, 教授 (70369172)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | カルシウム / カルシウムイメージング / 心臓 / エネルギー消費 / 酸素消費 / 収縮性 / 心筋細胞 / 興奮収縮連関 / カルシウムイオン / イメージング / 筋収縮 / GECIs / エネルギー代謝 / G-CaMP / 総機械的エネルギー / カルシウムトランジェント / 遺伝子組換え |
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| Outline of Final Research Achievements |
I attempted to develop a whole heart calcium imaging system with two different waves using modified G-CaMP-DsRed-coexpressed transgenic rat model to investigate the relationship among cardiac contractility, oxygen consumption, and intracellular calcium handling in the blood-perfused excised heart preparation. I just have to overcome a couple of problems for measuring accurate calcium transient. Now, I try to find the effective breakthrough.
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