The molecular basis of improving learning function with maternal experiences of pregnancy-delivery- pup rearing
| Project/Area Number |
25460321
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | St. Marianna University School of Medicine |
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Principal Investigator |
Nagatani Miyako 聖マリアンナ医科大学, 医学部, 准教授 (20450611)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUSHIMA Atsushi 聖マリアンナ医科大学, 医学部, 助教 (10442716)
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| Co-Investigator(Renkei-kenkyūsha) |
FUNABASHI Toshiya 聖マリアンナ医科大学, 医学部, 教授 (70229102)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 妊娠 / 出産 / 子育て / 学習 / 海馬 / AMPA / AMPA受容体 / 記憶 / 可塑性 / 学習機能 / 生殖生理学 / 神経内分泌 |
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| Outline of Final Research Achievements |
Behavioral changes during postpartum period are well documented in rats. In previous study, we demonstrated that changes in sensitivity to estrogen after delivery by comparing experimental groups of primiparity rats and nulliparity controls at the same age. In this study consisting of the similar groups, five-weeks postpartum rats that resumed estrus cycle after weaning were subjected in Y-maze tests. In electrophysiological study, we used a protocol for inducing long-term potentiation using whole-cell recording to pair low-frequency synaptic stimulation with a depolarizing voltage-clamp pulse. Furthermore, the expression level of GluR 1 and 2 was analyzed in the hippocampus by western blot. Improved performance of primiparous rats was found in Y maze. The expression of GluR 2 level was increased in the hippocampus of primiparous rats. Taken together, reproductive experience could change hippocampal function leading to improve spatial learning.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Impairments in brain-derived neurotrophic factor-induced glutamate release in cultured cortical neurons derived from rats with intrauterine growth retardation: possible involvement of suppression of TrkB/phospholipase C-γ activation.2014
Author(s)
Numakawa T, Matsumoto T, Ooshima Y, Chiba S, Furuta M, Izumi A, Ninomiya-Baba M, Odaka H, Hashido K, Adachi N, Kunugi H.
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Journal Title
Neurochem Res.
Volume: 39(4)
Issue: 4
Pages: 785-92
DOI
Related Report
Peer Reviewed / Open Access
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