Examination of the in vivo effect of DIF, an inhibitor of G1 phase transition derived from Dictyostelium, as a new anti-cancer drug
| Project/Area Number |
25460334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
General pharmacology
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| Research Institution | Kyushu University |
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Principal Investigator |
Takahashi Fumi 九州大学, 医学(系)研究科(研究院), 講師 (50274436)
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| Co-Investigator(Renkei-kenkyūsha) |
IGAWA KAZUNOBU 九州大学, 先導物質化学研究所, 助教 (80401529)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 新規抗腫瘍薬 / 経口抗腫瘍薬 / 抗腫瘍薬 / ＧＳＫ－３活性化 / Wnt / サイクリンＤ１ / G1期特異的 / Wntシグナル伝達系 / 橋渡し研究 |
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| Outline of Final Research Achievements |
We reported that differentiation-inducing factor-1 (DIF-1), synthesized by Dictyostelium discoideum, inhibited proliferation of various tumor cell lines in vitro. However, it remained unexplored whether DIF-1 also inhibits tumor growth in vivo. In the present study, therefore, we examined in-vivo effects of DIF-1 using three cancer models: Mutyh-deficient mice with oxidative stress-induced intestinal tumors and nude mice xenografted with cancer cells, and lung metastasis model mice.
We found that oral administrated DIF-1 significantly suppressed tumor growth in all examined models.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.2015
Author(s)
Kubokura N, Takahashi-Yanaga F, Arioka M, Yoshihara T, Igawa K, Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, Matsumoto T, Kitazono T, Sasaguri T
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Journal Title
J Pharmacol Sci
Volume: 127
Issue: 4
Pages: 446-455
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo2015
Author(s)
Kubokura N, Takaha-Yanaga F,Arioka M, Yoshihara T, Igawa K,Tomooka K, Morimoto S, Nakatsu Y, Tsuzuki T, Nakabeppu Y, MatsumotoT, Kitazono T and Sasaguri T
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Journal Title
J. Phramcol. Sci.
Volume: in press
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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