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Function of CD147 in white matter lesions

Research Project

Project/Area Number 25460349
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General pharmacology
Research InstitutionNagasaki International University (2014-2015)
Fukuoka University (2013)

Principal Investigator

Nishioku Tsuyoshi  長崎国際大学, 薬学部, 准教授 (90435115)

Co-Investigator(Kenkyū-buntansha) YAMAUCHI Atsushi  福岡大学, 薬学部, 准教授 (90341453)
KOGA Mitsuhisa  福岡大学, 薬学部, 助教 (60570801)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsCD147 / 白質 / 大脳白質 / 白質障害 / シクロフィリンA / オリゴデンドロサイト / 脳血管性認知症
Outline of Final Research Achievements

Ischemic white matter lesions are the characteristic pathological changes in subcortical ischemic vascular dementia , a common form of vascular dementia. Demyelination of the central nervous system leads to progressive cognitive and motor dysfunction. CD147, a membrane glycoprotein of the immunoglobulin superfamily, is highly upregulated during dynamic cellular events including tissue remodelling. In this study, we studied expression of CD147 and a novel involvement of CD147 in white matter lesion animal model, cuprizone-induced demyelination. Mice were fed a diet containing 0.2% cuprizone for 5 weeks. Cuprizon treatment induces severe demyelination and microglial activation. We also found CD147 levels to be upregulated in the brain of cuprizone-induced demyelination mouse. These results provide new insights suggesting CD147 is a potential therapeutic target to inhibit white matter lesions.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2016 2015 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] CD147 promotes the formation of functional osteoclasts through NFATc1 signalling.2016

    • Author(s)
      Nishioku T, Terasawa M, Baba M, Yamauchi A, Kataoka Y
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 473(3) Issue: 2 Pages: 620-4

    • DOI

      10.1016/j.bbrc.2016.03.147

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paracellular Barrier and Tight Junction Protein Expression in the Immortalized Brain Endothelial Cell Lines bEND.3, bEND.5 and Mouse Brain Endothelial Cell 42013

    • Author(s)
      Watanabe T, Dohgu S, Takata F, Nishioku T, Nakashima A, Futagami K, Yamauchi A, Kataoka Y.
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 36 Issue: 3 Pages: 492-495

    • DOI

      10.1248/bpb.b12-00915

    • NAID

      130003382085

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] BMP4 is increased in the aortas of diabetic ApoE knockout mice andenhances uptake of oxidized low density lipoprotein into peritoneal macrophages.2013

    • Author(s)
      Koga M, Yamauchi A, Kanaoka Y, Jige R, Tsukamoto A, Teshima N, Nishioku T,Kataoka Y.
    • Journal Title

      J Inflamm

      Volume: 10(1) Issue: 1 Pages: 32-32

    • DOI

      10.1186/1476-9255-10-32

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 破骨細胞分化におけるCD147の役割2015

    • Author(s)
      西奥剛,寺澤真理子,馬場美咲,山田勝士,片岡泰文
    • Organizer
      日本薬学会 第135年会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-25 – 2015-03-28
    • Related Report
      2014 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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