Elucidating mechanisms of tumor development and histological typing of gastric cancer based on the analysis of molecular mechanism of gastric differentiation
Project/Area Number |
25460381
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Pathological medical chemistry
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Research Institution | The University of Tokyo |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
INADA Kenichi 藤田保健衛生大学, 医学部, 教授 (70246081)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 消化管分化 / 胃癌 / 胃分化 / 腸上皮化生 / 腸分化 / 胃がん / MUC5AC / gastric cancer / gut differentiation / gene regulation / gli |
Outline of Final Research Achievements |
We identified Cathepsin E (CTSE) as a new gastric marker, and also as an useful marker for signet-ring cell carcionoma of stomach. We also found the conserved upstream 15 bp sequence of MUC5AC plays a critical role on MUC5AC expression via the recruitment of Gli transcription factor to this region.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Comparative analysis of upper gastrointestinal endoscopy, double-contrast upper gastrointestinal barium X-ray radiography, and the titer of serum anti-Helicobacter pylori IgG focusing on the diagnosis of atrophic gastritis.2016
Author(s)
Yamamichi N, Hirano C, Takahashi Y, Minatsuki C, Nakayama C, Matsuda R, Shimamoto T, Takeuchi C, Kodashima S, Ono S, Tsuji Y, Fujishiro M, Wada R, Mitsushima T, Koike K.
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Journal Title
Gastric Cancer.
Volume: 19
Issue: 2
Pages: 670-675
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Atrophic gastritis and enlarged gastric folds diagnosed by double-contrast upper gastrointestinal barium X-ray radiography are useful to predict future gastric cancer development based on the 3-year prospective observation2016
Author(s)
Yamamichi N, Hirano C, Ichinose M, Takahashi Y, Minatsuki C, Matsuda R, Nakayama C, Shimamoto T, Kodashima S, Ono S, Tsuji Y, Niimi K, Sakaguchi Y, Kataoka Y, Saito I, Asada-Hirayama I, Takeuchi C, Yakabi S, Kaikimoto H, Matsumoto Y, Yamaguchi D, Kageyama-Yahara N, Fujishiro M, Wada R, Mitsushima T, Koike K
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Journal Title
Gastric Cancer
Volume: 印刷中
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Scheduled second-look endoscopy is not recommended after endoscopic submucosal dissection for gastric neoplasms (the SAFE trial): a multicentre prospective randomised controlled non-inferiority trial2015
Author(s)
Mochizuki S, Uedo N, Oda I, Kaneko K, Yamamoto Y, Yamashina T, Suzuki H, Kodashima S, Yano T, Yamamichi N, Goto O, Shimamoto T, Fujishiro M, Koike K; SAFE Trial Study Group
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Journal Title
GUT
Volume: 64
Issue: 3
Pages: 397-405
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Demonstration of the usefulness of epigenetic cancer risk prediction by a multicentre prospective cohort study2015
Author(s)
Asada K, Nakajima T, Shimazu T, Yamamichi N, Maekita T, Yokoi C, Oda I, Ando T, Yoshida T, Nanjo S, Fujishiro M, Gotoda T, Ichinose M, Ushijima T
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Journal Title
GUT
Volume: 64
Issue: 3
Pages: 388-396
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Trend and risk factors of diverticulosis in Japan: age, gender, and lifestyle/metabolic-related factors may cooperatively affect on the colorectal diverticula formation.2015
Author(s)
Yamamichi N, Shimamoto T, Takahashi Y, Sakaguchi Y, Kakimoto H, Matsuda R, Kataoka Y, Saito I, Tsuji Y, Yakabi S, Takeuchi C, Minatsuki C, Niimi K, Asada-Hirayama I, Nakayama C, Ono S, Kodashima S, Yamaguchi D, Fujishiro M, Yamaji Y, Wada R, Mitsushima T, Koike K.
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Journal Title
PLoS One.
Volume: 10
Issue: 4
Pages: e0123688-e0123688
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Polyglycolic acid sheets with fibrin glue can prevent esophageal stricture after endoscopic submucosal dissection.2015
Author(s)
Sakaguchi Y, Tsuji Y, Ono S, Saito I, Kataoka Y, Takahashi Y, Nakayama C, Shichijo S, Matsuda R, Minatsuki C, Asada-Hirayama I, Niimi K, Kodashima S, Yamamichi N, Fujishiro M, Koike K.
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Journal Title
Endoscopy.
Volume: 47
Issue: 04
Pages: 336-340
DOI
Related Report
Peer Reviewed
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[Journal Article] Polyglycolic acid sheets and fibrin glue decrease the risk of bleeding after endoscopic submucosal dissection of gastric neoplasms (with video).2015
Author(s)
Tsuji Y, Fujishiro M, Kodashima S, Ono S, Niimi K, Mochizuki S, Asada-Hirayama I, Matsuda R, Minatsuki C, Nakayama C, Takahashi Y, Sakaguchi Y, Yamamichi N, Koike K.
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Journal Title
Gastrointest Endosc.
Volume: 81
Issue: 4
Pages: 906-912
DOI
Related Report
Peer Reviewed
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[Journal Article] Video of the Month: A Novel Endoscopic Full-Thickness Resection for Early Gastric Cancer.2015
Author(s)
Niimi K, Aikou S, Kodashima S, Yagi K, Oya S, Yamaguchi D, Yamashita H, Yamamichi N, Fujishiro M, Koike K, Seto Y.
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Journal Title
Am J Gastroenterol.
Volume: 110
Issue: 11
Pages: 1535-1535
DOI
Related Report
Peer Reviewed
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[Journal Article] Associated factors of atrophic gastritis diagnosed by double-contrast upper gastrointestinal barium X-ray radiography: a cross-sectional study analyzing 6,901 healthy subjects in Japan.2014
Author(s)
Yamamichi N, Hirano C, Shimamoto T, Minatsuki C, Takahashi Y, Nakayama C, Matsuda R, Fujishiro M, Konno-Shimizu M, Kato J, Kodashima S, Ono S, Niimi K, Mochizuki S, Tsuji Y, Sakaguchi Y, Asada-Hirayama I, Takeuchi C, Yakabi S, Kakimoto H, Wada R, Mitsushima T, Ichinose M, Koike K
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Journal Title
PLoS One
Volume: 9
Issue: 10
Pages: e111359-e111359
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Gli regulates MUC5AC transcription in human gastrointestinal cells.2014
Author(s)
Kageyama-Yahara N, Yamamichi N, Takahashi Y, Nakayama C, Shiogama K, Inada K, Konno-Shimizu M, Kodashima S, Fujishiro M, Tsutsumi Y, Ichinose M, Koike K
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Journal Title
PLoS One
Volume: 9
Issue: 8
Pages: e106106-e106106
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Which route is accompanied by minimal discomfort when performing esophagogastroduodenoscopy with an ultrathin endoscope, transnasal or transoral?2014
Author(s)
Ono S, Niimi K, Fujishiro M, Takahashi Yu, Sakaguchi Y, Nakayama C, Minatsuki C, Matsuda R, Hirayama-Asada I, Tsuji Y, Mochizuki S, Kodashima S, Yamamichi N, Ozeki A, Matsumoto L, Ohike Y, Yamazaki T, Koike K.
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Journal Title
World J Gastroenterol.
Volume: 20
Issue: 17
Pages: 5045-5050
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Categorization of upper gastrointestinal symptoms is useful in predicting background factors and studying effects and usages of digestive drugs.2014
Author(s)
Yamamichi N, Shimamoto T, Sakaguchi Y, Takahashi Y, Kodashima S, Nakayama C, Minatsuki C, Ono S, Mochizuki S, Matsuda R, Asada-Hirayama I, Niimi K, Fujishiro M, Tsuji Y, Takeuchi C, Kakimoto H, Goto O, Mitsushima T, Koike K.
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Journal Title
PLoS One
Volume: 9
Issue: 2
Pages: e88277-e88277
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Endoscopic tissue shielding method with polyglycolic acid sheets and fibrin glue to cover wounds after colorectal endoscopic submucosal dissection (with video).2014
Author(s)
Tsuji Y, Ohata K, Gunji T, Shozushima M, Hamanaka J, Ohno A, Ito T, Yamamichi N, Fujishiro M, Matsuhashi N, Koike K.
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Journal Title
Gastrointest Endosc.
Volume: 79
Issue: 1
Pages: 151-155
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Cancer development based on chronic active gastritis and resulting gastric atrophy as assessed by serum levels of pepsinogen and Helicobacter pylori antibody titer.2014
Author(s)
Yoshida T, Kato J, Inoue I, Yoshimura N, Deguchi H, Mukoubayashi C, Oka M, Watanabe M, Enomoto S, Niwa T, Maekita T, Iguchi M, Tamai H, Utsunomiya H, Yamamichi N, Fujishiro M, Iwane M, Takeshita T, Ushijima T, Ichinose M
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Journal Title
Int J Cancer
Volume: 134
Issue: 6
Pages: 1445-1457
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Helicobacter pylori infection is positively associated with gallstones: a large-scale cross-sectional study in Japan.2014
Author(s)
Takahashi Y, Yamamichi N, Shimamoto T, Mochizuki S, Fujishiro M, Takeuchi C, Sakaguchi Y, Niimi K, Ono S, Kodashima S, Mitsushima T, Koike K.
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Journal Title
J Gastroenterol
Volume: 49
Issue: 5
Pages: 882-889
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Evaluation of a new image-enhanced endoscopic technology using band-limited light for detection of esophageal squamous cell carcinoma.2014
Author(s)
Kodashima S, Fujishiro M, Ono S, Niimi K, Mochizuki S, Asada-Hirayama I, Konno-Shimizu M, Matsuda R, Minatsuki C, Nakayama C, Takahashi Y, Sakaguchi Y, Yamamichi N, Tanaka C, Koike K.
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Journal Title
Dig Endosc.
Volume: 26
Issue: 2
Pages: 164-171
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Background factors of reflux esophagitis and non-erosive reflux disease: a cross-sectional study of 10,837 subjects in Japan.2013
Author(s)
Minatsuki C, Yamamichi N, Shimamoto T, Kakimoto H, Takahashi Y, Fujishiro M, Sakaguchi Y, Nakayama C, Konno-Shimizu M, Matsuda R, Mochizuki S, Asada-Hirayama I, Tsuji Y, Kodashima S, Ono S, Niimi K, Mitsushima T, Koike K.
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Journal Title
PLoS One
Volume: 8
Issue: 7
Pages: e69891-e69891
DOI
Related Report
Peer Reviewed
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[Journal Article] Elevated risk of recurrent colorectal neoplasia with Helicobacter pylori-associated chronic atrophic gastritis: A follow-up study of patients with endoscopically resected colorectal neoplasia.2013
Author(s)
Inoue I, Kato J, Yoshimura N, Maeda Y, Moribata K, Shingaki N, Deguchi H, Enomoto S, Maekita T, Ueda K, Iguchi M, Tamai H, Fujishiro M, Yamamichi N, Takeshita T, Ichinose M.
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Journal Title
Mol Clin Oncol.
Volume: 1
Pages: 75-82
Related Report
Peer Reviewed
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[Journal Article] No association of coffee consumption with gastric ulcer, duodenal ulcer, reflux esophagitis, and non-erosive reflux disease: a cross-sectional study of 8,013 healthy subjects in Japan.2013
Author(s)
Shimamoto T, Yamamichi N, Kodashima S, Takahashi Y, Fujishiro M, Oka M, Mitsushima T, Koike K.
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Journal Title
PLoS One
Volume: 8
Issue: 6
Pages: e65996-e65996
DOI
Related Report
Peer Reviewed
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