| Project/Area Number |
25460386
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUJII Nobutaka 京都大学, 薬学研究科, 名誉教授 (60109014)
OISHI Sinya 京都大学, 薬学研究科, 助教授 (80381739)
ITOH Shinji 京都大学, 医学研究科, 助教 (50362512)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Txnip / 糖尿病 / 癌 / インスリン抵抗性 / 低分子化合物 / スクリーニング / ケミカルバイオロジー / 創薬 / 癌抑制 / アルファアレスチン / イノベーション / TBP-2 / 化合物スクリーニング / 低分子化合物スクリーニング |
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| Outline of Final Research Achievements |
Thioredoxin interacting protein (Txnip)/TBP-2 plays an important role in cancer suppression and glucose metabolism. To elucidate the molecular mechanism of Txnip, we performed proteomics analyses and identified interacting molecules with Txnip. This finding provides a basis for developing approaches to control diabetes and cancer. We also performed screening and identified low molecular weight compounds which suppress glucose-induced augmentation of Txnip expression, enhance glucose uptake and ameliorate high glucose in an animal model. Using these compounds, we revealed the regulatory pathway of Txnip expression. These results open the road to unveil the unknown signal transduction pathway and to develop novel drugs to control diabetes.
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