Regulation of intestinal and hepatic immunity and metabolism by vitamin D receptor
| Project/Area Number |
25460394
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nihon University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SEKI Shuji 防衛医科大学校, 医学教育部医学科進学課程, 教授 (80531392)
UMEDA Kaori 日本大学, 医学部, 助手 (10445744)
ISHIZAWA Michiyasu 日本大学, 医学部, 助手 (30646542)
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| Research Collaborator |
YAMADA Sachiko
NISHIDA Shigeru
UMEDA Naoki
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ビタミンD受容体 / 肝障害 / クッパ－細胞 / NKT細胞 / 肝臓 / 胆汁酸 / サイトカイン / ビタミンD誘導体 / マクロファージ / 急性肝障害 / NK細胞 / クッパ-細胞 / 自然免疫 / インターロイキン6 |
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| Outline of Final Research Achievements |
We examined the roles of vitamin D receptor (VDR) in immunity and metabolism in the liver and intestine. We compared the effects of inflammatory stimulants, such as lipopolysaccharide and concanavalin A, on hepatic immune cells isolated from wild-type mice and VDR knockout mice and their in vivo effects. VDR deletion reduced the inflammatory response of Kupffer cells and NK cells against lipopolysaccharide and alleviated concanavalin A-induced hepatitis. Experiments using a chenodeoxycholic acid-containing diet showed that metabolism of chenodeoxycholic acid and lithocholic acid is disturbed in VDR knockout mice. The results show that VDR plays a role in the hepatic immunity and bile acid metabolism. We developed selective VDR modulators, which should be useful for future studies.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Synthesis, Biological Activities and X-ray Crystal Structural Analysis of 25-Hydroxy-25(or 26)-adamantyl-17-[20(22),23-diynyl]-21-norvitamin D Compounds2015
Author(s)
Yusuke Watarai, Michiyasu Ishizawa, Teikichi Ikura, Flavia C. M. Zacconi, Shigeyuki Uno, Nobutoshi Ito, Antonio Mourino, Hiroaki Tokiwa, Makoto Makishima, and Sachiko Yamada
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Journal Title
J.Med.Chem.
Volume: 58 (24)
Issue: 24
Pages: 9510-9521
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Combination of Triple Bond and Adamantane Ring on the Vitamin D Side Chain Produced Partial Agonists for Vitamin D Receptor2014
Author(s)
Takeru Kudo, Michiyasu, Ishizawa, Kazuki Maekawa, Makoto Nakabayashi, Yusuke Watarai, Hikaru Uchida, Hiroaki Tokiwa, Teikichi Ikura, Nobutoshi Ito, Makoto Makishima, Sachiko Yamada,
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Journal Title
J. Med. Chem.
Volume: 57(10)
Issue: 10
Pages: 4073-4087
DOI
Related Report
Peer Reviewed
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