| Project/Area Number |
25460403
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Tohoku University |
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Principal Investigator |
TAMIYA Gen 東北大学, 東北メディカル・メガバンク機構, 教授 (10317745)
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| Co-Investigator(Kenkyū-buntansha) |
UEKI Masao 久留米大学, バイオ統計センター, 講師 (10515860)
NAKAMURA Tomohiro 東北大学, 東北メディカル・メガバンク機構, 助教 (30537923)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 遺伝統計学 / 人類遺伝学 / コホート研究 / 高次元変数選択法 / 遺伝子×環境相互作用 |
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| Outline of Final Research Achievements |
For rapid and flexibility extraction of genetic and environmental frisk actors from large-scale prospective genomic cohort data, we propose a new genetic statistical method utilizing a framework of the high-dimensional variable selection under p >> n condition of the high-dimensional and small-sample size data from such genomic cohort study; at first we extended Sure Independence Screening, which combines ranking (marginal regression) and variable selection (penalized regression), to gene × environment interaction data. Finally, we improved our software program by reflecting these findings.
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