| Project/Area Number |
25460415
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | University of Yamanashi |
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Principal Investigator |
KONDO Tetsuo 山梨大学, 総合研究部, 准教授 (30334858)
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| Co-Investigator(Kenkyū-buntansha) |
KATOH Ryohei 山梨大学, 総合研究部, 教授 (30152755)
NAKAZAWA Tadao 山梨大学, 総合研究部, 准教授 (10345704)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 甲状腺癌 / Runx2 / 低酸素 / 分子病理 / 人体病理学 / 内分泌 / 甲状腺 / 上皮間葉移行 / mTOR |
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| Outline of Final Research Achievements |
The mammalian runt-related transcription factor (Runx) genes, including RUNX1 (AML1/CBFA2), RUNX2 (AML2/CBFA1) and RUNX3 (AML3/CBFA3), encode transcription factors that are master regulators of proliferation and differentiation during embryonic development. Enhanced Runx2 is functionally linked to tumor invasion and metastasis of thyroid carcinoma by regulating EMT-related molecules, matrix metalloproteinases and angiogenic/lymphangiogenic factors. In this study, we demonstrated that hypoxic stimulation due to CoCl2 or hypoxic incubator (O2 1%) induce downregulation of Runx2 mRNA in thyroid carcinoma cell lines. Our data suggested that Runx2 is upregulated in the invasive area, while down regulated in the hypoxic area of the thyroid cancer.
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