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Regulation of Runx2 through hypixia and mTOR pathway in thyroid cancer

Research Project

Project/Area Number 25460415
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionUniversity of Yamanashi

Principal Investigator

KONDO Tetsuo  山梨大学, 総合研究部, 准教授 (30334858)

Co-Investigator(Kenkyū-buntansha) KATOH Ryohei  山梨大学, 総合研究部, 教授 (30152755)
NAKAZAWA Tadao  山梨大学, 総合研究部, 准教授 (10345704)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords甲状腺癌 / Runx2 / 低酸素 / 分子病理 / 人体病理学 / 内分泌 / 甲状腺 / 上皮間葉移行 / mTOR
Outline of Final Research Achievements

The mammalian runt-related transcription factor (Runx) genes, including RUNX1 (AML1/CBFA2), RUNX2 (AML2/CBFA1) and RUNX3 (AML3/CBFA3), encode transcription factors that are master regulators of proliferation and differentiation during embryonic development. Enhanced Runx2 is functionally linked to tumor invasion and metastasis of thyroid carcinoma by regulating EMT-related molecules, matrix metalloproteinases and angiogenic/lymphangiogenic factors. In this study, we demonstrated that hypoxic stimulation due to CoCl2 or hypoxic incubator (O2 1%) induce downregulation of Runx2 mRNA in thyroid carcinoma cell lines. Our data suggested that Runx2 is upregulated in the invasive area, while down regulated in the hypoxic area of the thyroid cancer.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (29 results)

All 2015 2014 2013 Other

All Journal Article (12 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 4 results) Presentation (12 results) (of which Int'l Joint Research: 1 results,  Invited: 6 results) Book (2 results) Remarks (3 results)

  • [Journal Article] 次世代シーケンサーによる甲状腺癌ゲノム解析のインパクト2015

    • Author(s)
      近藤哲夫
    • Journal Title

      Thyroid Cancer Explore

      Volume: 1 Pages: 95-99

    • Related Report
      2015 Annual Research Report
  • [Journal Article] 低分化癌:甲状腺癌の病理診断 新たな展開2015

    • Author(s)
      近藤哲夫
    • Journal Title

      日本甲状腺学会雑誌

      Volume: 6 Pages: 113-118

    • Related Report
      2015 Annual Research Report
  • [Journal Article] High prevalence of the MYD88 mutation in testicular lymphoma: Immunohistochemical and genetic analyses.2015

    • Author(s)
      Oishi N, Kondo T, Nakazawa T, Mochizuki K, Tanioka F, Oyama T, Yamamoto T, Iizuka J, Tanabe K, Shibata N, Kirito K, Katoh R
    • Journal Title

      Virchows Arch

      Volume: 467 Pages: 427-436

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multicentric occurrence of multiple papillary thyroid carcinomas -HUMARA and BRAF mutation analysis.2015

    • Author(s)
      Nakazawa T, Kondo T, Tahara I, Kasai K, Inoue T, Oishi N, Mochizuki K, Kubota T, Katoh R
    • Journal Title

      Cancer Med

      Volume: 4 Pages: 1272-1280

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low frequency of PAX8-PPARγ rearrangement in follicular thyroid carcinomas in Japanese patients.2015

    • Author(s)
      Mochizuki K, Kondo T, Oishi N, Tahara I, Inoue T, Kasai K, Nakazawa T, Okamoto T, Shibata N, Katoh R.
    • Journal Title

      Pathol Int

      Volume: 65 Pages: 250-253

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Heterogeneous Immunoreactivity of Emerin, a Nuclear Envelope LEM-domain Protein, in Normal Thyroid Follicles2014

    • Author(s)
      Jieying W, Kondo T, Yamane T, Nakazawa T, Oishi N, Kawasaki T, Mochizuki K, Dongfeng N, Katoh R
    • Journal Title

      ACTA HISTOCHEMICA ET CYTOCHEMICA

      Volume: 47 Issue: 6 Pages: 289-294

    • DOI

      10.1267/ahc.14041

    • NAID

      130004703748

    • ISSN
      0044-5991, 1347-5800
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Localized Langerhans cell histiocytosis of the thymus with BRAF V600E mutation: a case report with immunohistochemical and genetic analyses.2014

    • Author(s)
      Oishi N, Kondo T, Mochizuki K, Inoue T, Kasai K, Nakazawa T, Mitsumori T, Katoh R
    • Journal Title

      Hum Pathol.

      Volume: 45(6) Pages: 1302-5

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Thyroid-like low-grade nasopharyngeal papillary adenocarcinoma: case report and literature review.2014

    • Author(s)
      Oishi N, Kondo T, Nakazawa T, Mochizuki K, Kasai K, Inoue T, Yamamoto T, Watanabe H, Hatsushika K, Masuyama K, Katoh R
    • Journal Title

      Pathol Res Pract

      Volume: 210(12) Issue: 12 Pages: 1142-5

    • DOI

      10.1016/j.prp.2014.04.020

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Gastric adenocarcinoma of pyloric gland type with high-grade malignancy.2014

    • Author(s)
      Mochizuki K, Kondo T, Tahara I, Inoue T, Kasai K, Oishi N, Nakazawa T, Komiyama A, Katoh R.
    • Journal Title

      Pathol Int.

      Volume: 65(3) Issue: 3 Pages: 148-50

    • DOI

      10.1111/pin.12241

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 甲状腺低分化癌:疾患概念と病理診断の実際2013

    • Author(s)
      近藤哲夫, 中澤匡男, 加藤良平
    • Journal Title

      診断病理

      Volume: 30 Pages: 185-190

    • Related Report
      2013 Research-status Report
  • [Journal Article] 病気のはなし:甲状腺髄様癌2013

    • Author(s)
      近藤哲夫, 中澤匡男, 加藤良平.
    • Journal Title

      検査と技術

      Volume: 31 Pages: 50-56

    • Related Report
      2013 Research-status Report
  • [Journal Article] 甲状腺癌の分子メカニズム 最近の知見2013

    • Author(s)
      近藤哲夫, 望月邦夫, 中澤匡男
    • Journal Title

      病理と臨床

      Volume: 67 Pages: 419-427

    • Related Report
      2013 Research-status Report
  • [Presentation] 多段階発癌モデルからみら鑑別困難、濾胞性腫瘍2015

    • Author(s)
      近藤哲夫
    • Organizer
      第54回日本臨床細胞学会秋期大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Characteristics of childhood papillary thyroid carcinoma2015

    • Author(s)
      Tetsuo Kondo
    • Organizer
      39th Europian congress of cytology
    • Place of Presentation
      Paris, France
    • Year and Date
      2015-09-20
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 甲状腺癌における低分化成分の臨床的意義2015

    • Author(s)
      近藤哲夫
    • Organizer
      第104回日本病理学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] 状腺の正常、過形成、腫瘍における核膜蛋白の発現2014

    • Author(s)
      WANG JIE YING, 近藤哲夫、加藤良平
    • Organizer
      第32回内分泌代謝学サマーセミナー
    • Place of Presentation
      富士レークホテル(山梨県・南都留郡)
    • Year and Date
      2014-07-10 – 2014-07-12
    • Related Report
      2014 Research-status Report
  • [Presentation] 低分化 (充実、索状、島状構造)成分を伴う甲状腺癌の臨床病理学的検討2014

    • Author(s)
      近藤哲夫
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島県・広島市)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] 甲状腺癌の機能形態学的攻究 -甲状腺濾胞の成り立ちから腫瘍まで-2014

    • Author(s)
      加藤良平
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島県・広島市)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 多発甲状腺乳頭癌の発生機序2014

    • Author(s)
      中澤匡男
    • Organizer
      第103回日本病理学会総会
    • Place of Presentation
      広島国際会議場(広島県・広島市)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Research-status Report
  • [Presentation] Putative anti-tumor properties of TTF- in thyroid carcinogenesis2013

    • Author(s)
      近藤哲夫
    • Organizer
      第102回日本病理学会総会
    • Place of Presentation
      ロイトン札幌(北海道、札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 病理細胞診セミナー: 甲状腺未分化癌2013

    • Author(s)
      近藤哲夫
    • Organizer
      第52回日本臨床細胞学会秋季大会
    • Place of Presentation
      大阪国際会議場(大阪府、大阪市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 基礎甲状腺学セミナー: 甲状腺癌のプログレッションとエピジェネティクス異常2013

    • Author(s)
      近藤哲夫、加藤良平
    • Organizer
      第56回日本甲状腺学会
    • Place of Presentation
      和歌山県民文化会館(和歌山県、和歌山市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] エピジェネティック因子の組織細胞化学 甲状腺癌のプログレッションとエピジェネティクス修飾因子.2013

    • Author(s)
      近藤哲夫
    • Organizer
      第54回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      航空会館(東京都、港区)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Childhood thyroid cancer: Histopathological and clinicopathological characteristics2013

    • Author(s)
      近藤哲夫
    • Organizer
      第59回日本病理学会秋期特別総会
    • Place of Presentation
      甲府富士屋ホテル(山梨県、甲府市)
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 第18章 内分泌. 標準病理学 第5版2015

    • Author(s)
      近藤哲夫(分担共著)
    • Total Pages
      32
    • Publisher
      医学書院
    • Related Report
      2015 Annual Research Report
  • [Book] 標準病理学 第5版 第18章内分泌2015

    • Author(s)
      近藤哲夫(分担執筆)
    • Total Pages
      878
    • Publisher
      医学書院
    • Related Report
      2014 Research-status Report
  • [Remarks] 山梨大学研究者総覧

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_Index.Main?

    • Related Report
      2015 Annual Research Report
  • [Remarks] 山梨大学 研究者総覧 近藤哲夫

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispDetail.Scholar

    • Related Report
      2014 Research-status Report
  • [Remarks] 山梨大学研究者総覧

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_Index.Main?

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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