Investigation of the peculiar invasion/metastasis mechanism of breast invasive micropapillary carcinoma.
| Project/Area Number |
25460425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Rin 久留米大学, 医学部, 准教授 (10309750)
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| Co-Investigator(Renkei-kenkyūsha) |
KUREBAYASHI Junichi 川崎医科大学, 医学部, 教授 (10248255)
MORIYA Takuya 川崎医科大学, 医学部, 教授 (00230160)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 浸潤性微小乳頭癌 / リンパ節転移 / 免疫染色 / 乳癌 / マイクロアレイ / 予後 / BC-1514 / CD1D / 病理組織 / 極性逆転 |
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| Outline of Final Research Achievements |
Invasive micropapillary carcinoma has the peculiar pseudopapillary and/or micropapillary structures. Invasive micropapillary carcinoma has been known to have more lymph vessel infiltration and nodal involvement than usual invasive ductal carcinoma. However, the mechanism of invasive micropappillary carcinoma has not been well understood. By immunohistochemical method, C21orf118(BC-1514) has higher expression in invasive micropapillary carcinoma than usual invasive ductal carcinoma. CD1D and PJA2 showed their lower expression in micropapillary carcinoma than usual carcinoma. CD1D has the significant inverse correlation with venous invasion (p=0.002) and lymph node metastasis (p=0.047). CD1D might suppress lymph node metastasis.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] CD8+ tumor-infiltrating lymphocytes contribute to spontaneous "healing" in HER2-positive ductal carcinoma in situ.2016
Author(s)
Morita M, Yamaguchi R, Tanaka M, Tse GM, Yamaguchi M, Kanomata N, Naito Y, Akiba J, Hattori S, Minami S, Eguchi S, Yano H.
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Journal Title
Cancer Med
Volume: (epub)
Issue: 7
Pages: 1607-1618
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Management of breast papillary lesions diagnosed in ultrasound-guided vacuum-assisted and core needle biopsies.2015
Author(s)
Yamaguchi R, Tanaka M, Tse GM, Yamaguchi M, Terasaki H, Hirai Y, Nonaka Y, Morita M, Yokoyama T, Kanomata N, Naito Y, Akiba J, Yano H.
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Journal Title
Histopatholog
Volume: 66
Issue: 4
Pages: 565-576
DOI
Related Report
Peer Reviewed
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[Journal Article] Assessment of the Ki67 labeling index: a Japanese validation ring study.2014
Author(s)
Niikura N, Sakatani T, Arima N, Ohi Y, Honma N, Kanomata N, Yoshida K, Kadoya T, Tamaki K, Kumaki N, Iwamoto T, Sugie T, Moriya T
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Journal Title
Breast Cancer
Volume: 21
Issue: 1
Pages: 1-9
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Assessment of the Ki67 labeling index: a Japanese validation ring study.2014
Author(s)
Niikura N, Sakatani T, Arima N, Ohi Y, Honma N, Kanomata N, Yoshida K, Kadoya T, Tamaki K, Kumaki N, Iwamoto T, Sugie T, Moriya T.
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Journal Title
Breast Cancer
Volume: (epub)
Related Report
Peer Reviewed
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[Journal Article] 血清CA19-9異常高値にて発見された甲状腺乳頭癌の1例2014
Author(s)
藤井 清香, 田中 克浩, 太田 裕介, 小池 良和, 山下 哲正, 下 登志朗, 水藤 晶子, 山本 裕, 椎木 滋雄, 紅林 淳一, 園尾 博司, 鹿股 直樹, 森谷 卓也
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Journal Title
日本内分泌・甲状腺外科学会雑誌
Volume: 31
Pages: 154-157
NAID
Related Report
Peer Reviewed
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[Presentation] 進行再発乳癌患者における胸水セルブロック病理学的評価の検討2016
Author(s)
岸野瑛美, 齋藤亙, 山下哲正, 小倉一恵, 山本正利, 野村長久, 山本裕, 田中克浩, 紅林淳一, 鹿股直樹, 森谷卓也
Organizer
第22回日本乳腺疾患研究会
Place of Presentation
大宮ソニックシティ(埼玉県・さいたま市）
Year and Date
2016-02-26
Related Report
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