| Project/Area Number |
25460425
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAGUCHI Rin 久留米大学, 医学部, 准教授 (10309750)
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| Co-Investigator(Renkei-kenkyūsha) |
KUREBAYASHI Junichi 川崎医科大学, 医学部, 教授 (10248255)
MORIYA Takuya 川崎医科大学, 医学部, 教授 (00230160)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 浸潤性微小乳頭癌 / リンパ節転移 / 免疫染色 / 乳癌 / マイクロアレイ / 予後 / BC-1514 / CD1D / 病理組織 / 極性逆転 |
|---|
| Outline of Final Research Achievements |
Invasive micropapillary carcinoma has the peculiar pseudopapillary and/or micropapillary structures. Invasive micropapillary carcinoma has been known to have more lymph vessel infiltration and nodal involvement than usual invasive ductal carcinoma. However, the mechanism of invasive micropappillary carcinoma has not been well understood. By immunohistochemical method, C21orf118(BC-1514) has higher expression in invasive micropapillary carcinoma than usual invasive ductal carcinoma. CD1D and PJA2 showed their lower expression in micropapillary carcinoma than usual carcinoma. CD1D has the significant inverse correlation with venous invasion (p=0.002) and lymph node metastasis (p=0.047). CD1D might suppress lymph node metastasis.
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