Association of histological diversity and genetic alteration of gastric cancer in the elderly

• Project/Area Number: 25460428
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology
• Principal Investigator: ARAI Tomio 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (20232019)
• Co-Investigator(Renkei-kenkyūsha): IZUMIYAMA Naotaka 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 助手 (10158751)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 胃癌 / 高齢者 / ミスマッチ修復遺伝子 / マイクロサテライト不安定性

Outline of Final Research Achievements

Gastric cancer in the elderly shows histological diversity. Gastric cancer with microsatellite instability (MSI) increases with advancing age and solid-type poorly differentiated adenocarcinoma (por1) is histological type which demonstrates the highest proportion of MSI. Pathologically, the por1 cancer is closely related with older age, female predominance, lower third location and concomitant glandular component. Although gastric cancer infrequently shows KRAS and BRAF mutations, the por1 cancer demonstrated rather higher proportion of the mutations. Thus, these results suggest that the por1 cancer is a peculiar type of histology, especially in the elderly women.

Research Products

• [Int'l Joint Research] Maastricht University Medical Center(オランダ)
• [Int'l Joint Research] National Cancer Centre(シンガポール)
• [Int'l Joint Research] University of Leeds(英国)
• [Journal Article] Signatures of tumour immunity distinguish Asian and non-Asian gastric adenocarcinomas (2015)
  • Author(s): Lin SJ, Gagnon-Bartsch JA, Tan IB, Earle S, Ruff L, Pettinger K, Ylstra B, van Grieken N, Rha SY, Chung HC, Lee JS, Cheong JH, Noh SH, Aoyama T, Miyagi Y, Tsuburaya A, Yoshikawa T, Ajani JA, Boussioutas A, Yeoh KG, Yong WP, So J, Lee J, Kang WK, Kim S, Kameda Y, Arai T, Zur Hausen A, Speed TP, Grabsch HI, Tan P
  • Journal Title: Gut Volume: 64 Issue: 11 Pages: 1721-1731
  • DOI: 10.1136/gutjnl-2014-308252
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 高齢者がんの臨床病理学的特徴 (2015)
  • Author(s): 新井冨生，松田陽子，相田順子，田久保海誉
  • Journal Title: 日本臨床 Volume: 73 Pages: 1409-1417
  • NAID: 10027914023
• [Journal Article] 食道胃接合部腺癌の病理学的特徴 (2015)
  • Author(s): 新井冨生，松田陽子，濱保英樹，関 敦子，野中敬介，相田順子，田久保海誉
  • Journal Title: 胃と腸 Volume: 50 Pages: 1109-1117
• [Journal Article] Association analysis of single nucleotide polymorphisms in miR-146a and miR-196a2 on the prevalence of cancer in elderly Japanese: a case-control study (2014)
  • Author(s): Parlayan C, Ikeda S, Sato N, Sawabe M, Muramatsu M, Arai T
  • Journal Title: Asian Pac J Cancer Prev Volume: 15 Issue: 5 Pages: 2101-2107
  • DOI: 10.7314/apjcp.2014.15.5.2101
  • Peer Reviewed / Open Access
• [Journal Article] Gastric high-grade dysplasia can be associated with submucosalinvasion: evaluation of its prevalence in a series of 121 endoscopically resected specimens (2014)
  • Author(s): Sakurai U, Lauwers GY, Vieth M, Sawabe M, Arai T, Yoshida T, Aida J, Takubo K
  • Journal Title: Am J Surg Pathol Volume: 38 Issue: 11 Pages: 1545-1550
  • DOI: 10.1097/pas.0000000000000274
  • Peer Reviewed
• [Journal Article] Association analysis of single nucleotide polymorphisms in miR-146a and miR-196a2 on the prevalence of cancer in elderly Japanese: a case-control study. (2014)
  • Author(s): Parlayan C, Ikeda S, Sato N, Sawabe M, Muramatsu M, Arai T
  • Journal Title: Asian Pac J Cancer Prev Volume: 5 Pages: 2101-2107
  • Peer Reviewed
• [Journal Article] 最新胃癌学―基礎と臨床の最新研究動向―分子生物学 DNA修復遺伝子 (2014)
  • Author(s): 新井冨生，櫻井うらら，津山直子，田久保海誉
  • Journal Title: 日本臨牀 Volume: 72増刊号1 Pages: 100-104
• [Journal Article] Frequent microsatellite instability in papillary and solid-type, poorly-differentiated adenocarcinomas of the stomach (2013)
  • Author(s): Arai T, Sakurai U, Sawabe M, Honma N, Aida J, Kanazawa N, Kuroiwa K, Takubo K
  • Journal Title: Gastric Cancer Volume: 6 Issue: 4 Pages: 505-512
  • DOI: 10.1007/s10120-012-0226-6
  • NAID: 40019845240
  • Peer Reviewed
• [Journal Article] hTERT promoter polymorphism, -1327C>T, is associated with the risk of epithelial cancer (2013)
  • Author(s): Iizuka T, Sawabe M, Takubo K, Suzui M, Arai T
  • Journal Title: SpringerPlus Volume: 2 Pages: 249-249
  • Peer Reviewed
• [Journal Article] KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: Results from a large international multicentre study (2013)
  • Author(s): van Grieken NC, Aoyma T, Chambers PA, Bottomley D, Ward LC, et al.
  • Journal Title: Br J Cancer Volume: 108 Issue: 7 Pages: 1495-1501
  • DOI: 10.1038/bjc.2013.109
  • Peer Reviewed
• [Presentation] Digestive Diseases Pathology, ESP/EEG Joint Symposium, Early neoplastic lesions in the digestive system: Update in early oesophageal squamous neoplasia (2015)
  • Author(s): Arai T
  • Organizer: The 27th Meeting of the European Congress of Pathology
  • Place of Presentation: Belgrade, Serbia
  • Year and Date: 2015-09-09
  • Int'l Joint Research / Invited
• [Presentation] Frequent microsatellite instability and absent MLH1 expression in solid-type poorly differentiated adenocarcinoma of the stomach (2015)
  • Author(s): 30. Arai T, Matsuda Y, Aida J, Takubo K
  • Organizer: 9th Congress of Asia Pacific International Academy of Pathology
  • Place of Presentation: Brisbane (Australia)
  • Year and Date: 2015-06-04 – 2015-06-07
• [Presentation] Frequent microsatellite instability and absent MLH1 expression in solid-type poorly differentiated adenocarcinoma of the stomach (2015)
  • Author(s): Arai T, Matsuda Y, Aida J, Takubo K
  • Organizer: The 9th Asia Pacific Interational Academy of Pathology Congress
  • Place of Presentation: Brisbane, Australia
  • Year and Date: 2015-06-04
  • Int'l Joint Research
• [Presentation] 高齢者胃充実型低分化腺癌の臨床病理学的特徴 (2015)
  • Author(s): 新井冨生，松田陽子，濱保英樹，本間尚子，相田順子，田久保海誉
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場（愛知県・名古屋市）
  • Year and Date: 2015-05-01
• [Presentation] 高齢者胃充実型低分化腺癌の臨床病理学的特徴 (2015)
  • Author(s): 新井冨生，松田陽子，濱保英樹，本間尚子，相田順子，田久保海誉
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2015-05-01
• [Presentation] Immunohistochemical detection of trastuzumab binding in gastric cancer: comparison with conventional HER2 immunohistochemistry (2014)
  • Author(s): Arai T, Kinoshita M, Shirahata H, Hamashima Y, Suzuki A, Matsuda Y, Aida J, Takubo K, Grabsch HI
  • Organizer: 26th Congress of the European Society of Pathology
  • Place of Presentation: London
  • Year and Date: 2014-09-01
• [Presentation] 高齢者のがんの特徴と治療．高齢者がんの臨床病理学的特徴 (2014)
  • Author(s): 新井冨生
  • Organizer: 日本臨床腫瘍学会・日本癌学会・日本血液学会合同シンポジウム
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2014-07-17
  • Invited
• [Presentation] Cell differentiation in neuroendocrine tumors in gastrointestinal tract: where do neuroendocrine cells come from?
  • Author(s): Arai T
  • Organizer: 8th Asia-Pacific International Academy of Pathology Congress
  • Place of Presentation: Busan, Korea
  • Invited
• [Presentation] 胃乳頭腺癌と充実型低分化腺癌は高頻度にマイクロサテライト不安定性を示す
  • Author(s): 新井冨生，櫻井うらら，本間尚子，相田順子，沢辺元司，田久保海誉
  • Organizer: 第102回日本病理学会総会
  • Place of Presentation: 札幌
• [Book] 腫瘍病理鑑別診断アトラス胃癌第2版：乳頭腺癌 (2015)
  • Author(s): 新井冨生
  • Publisher: 文光堂
• [Book] 腫瘍病理鑑別診断アトラス胃癌第2版：その他の癌（絨毛癌・未分化癌） (2015)
  • Author(s): 新井冨生
  • Publisher: 文光堂
• [Remarks] 高齢者がん研究グループ ホームページについて
  • URL: http://www.ttaggg-rtgp.org/
• [Remarks] 高齢者がん研究
  • URL: http://www.tmghig.jp/J_TMIG/kenkyu/team/koureishagan.html
• [Remarks] Research Team for Geriatric Pathology
  • URL: http://www.ttaggg-rtgp.org/