Establishment of polychromatic FACS analysis for diagnosis of glomeluronephritis instead of pathology

Research Project

Project/Area Number	25460464
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Human pathology
Research Institution	Nippon Medical School
Principal Investigator	Iwahori Toru 日本医科大学, 医学(系)研究科(研究院), 研究員 (00366105)
Co-Investigator(Kenkyū-buntansha)	SHIMIZU Akira 日本医科大学, 大学院医学研究科, 教授 (00256942)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords	多重染色フローサイトメトリー / 多重染色フローサイトメトリー法 / IgA腎症 / 扁摘
Outline of Final Research Achievements	Progression of glomerulonephritis is associated of cellular- and humoral- immunological enhancement due to cytokine network including dendritic cell, T cell, macropahage and so on and also break of autoimmunne system. We have distinguished the network of immunne system in blood by analysis of polychromatic flow cytmetory. We also established a basic analysis system for analyzing of association of blood and tonsil.