Immunohistochemical analysis of Thy-1 and PDGF in IgG4-related disease

• Project/Area Number: 25460465
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Human pathology
• Research Institution: Kanazawa Medical University
• Principal Investigator: KUROSE Nozomu 金沢医科大学, 医学部, 助教 (10319048)
• Co-Investigator(Kenkyū-buntansha): Minato Hiroshi 金沢医科大学, 医学部, 教授 (10293367) ; MASAKI Yasufumi 金沢医科大学, 医学部, 教授 (40238895)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: IgG4関連疾患 / 線維化 / IgG関連疾患 / IgG4 / CD248 / Thy-1 / fibrosis / PDGFRα / PDGFRβ

Outline of Final Research Achievements

To quantify the degree of fibrosis in various organs in IgG4 related disease, and to clarify the mechanism of the fibrosis in IgG4 related disease, this study was performed. Pericyte and myofibroblast cells were thought to be related to fibrosis of IgG4 related disease. Compared to non-IgG4 related disease, the degree of fibrosis was significantly higher. It was possible to quantify the degree of fibrosis in IgG4 related disease.

Research Products

• [Journal Article] CD14(+) follicular dendritic cells in lymphoid follicles may play a role in the pathogenesis of IgG4-related disease. (2015)
  • Author(s): Satoh-Nakamura T, Kurose N, Kawanami T, Nakamura T, Iwao-Kawanami H, Nakajima A, Miki M, Sakai T, Fujita Y, Tanaka M, Fukushima T, Masaki Y
  • Journal Title: Biomed Res. Volume: 36 Pages: 143-153
  • NAID: 130005065277
  • Peer Reviewed
• [Journal Article] Japanese variant of multicentirc cattleman's disease associated with serositis and thrombocytopenia-a report of two cases: Is TAFRO syndrome(Castleman-Kojima Disease) a distinct clinicopathological entity? (2013)
  • Author(s): Y.Masaki, A.Nakajima, H.Iwao, N.Kurose, T.Sato, T.Nakamura, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara
  • Journal Title: J. Clin. Exp. Hematop Volume: 53 Pages: 79-85
  • Peer Reviewed
• [Presentation] Inflammatory monocytes may play a role of pathophysiology in IgG4-RD (2014)
  • Author(s): T.Satoh, T.Nakamura, N.Kurose, H.Iwao, A.Nakajima, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, Y.Masaki
  • Organizer: The 76th Annual Meeting of the Japanese Society of Hematology
  • Place of Presentation: 大阪国際会議場(大阪府大阪市)
  • Year and Date: 2014-10-31 – 2014-11-02
• [Presentation] 頭蓋内に限局したRosai-Dorfman病の1例 (2013)
  • Author(s): 土屋 直子, 道合万里子, 北楯優隆, 近藤 環, 的場宗孝, 利波久雄, 笹川泰生, 赤井卓也, 飯塚秀明, 黒瀬 望, 野島孝之
  • Organizer: 第49回日本医学放射線学会秋季大会
  • Place of Presentation: 名古屋国際会議場
• [Presentation] 髄膜腫に類似した画像を呈した Rosai-Dorfman disease の1例 (2013)
  • Author(s): 赤井卓也, 笹川泰生, 立花 修, 飯塚秀明, 黒瀬 望
  • Organizer: 第31回日本脳腫瘍病理学会
  • Place of Presentation: KFC Hall 国際ファッションセンター (東京都墨田区)
• [Presentation] 多発肺結節影を伴ったIgG4関連疾患の一例 (2013)
  • Author(s): 森田 貴義, 正木 康史, 加藤 保宏, 川崎 貴裕, 小林 久美子, 黒瀬 望, 梅原 久範, 藤原 弘士
  • Organizer: 第57回日本リウマチ学会総会・学術集会
  • Place of Presentation: 国立京都国際会館