| Project/Area Number |
25460465
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
KUROSE Nozomu 金沢医科大学, 医学部, 助教 (10319048)
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| Co-Investigator(Kenkyū-buntansha) |
Minato Hiroshi 金沢医科大学, 医学部, 教授 (10293367)
MASAKI Yasufumi 金沢医科大学, 医学部, 教授 (40238895)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | IgG4関連疾患 / 線維化 / IgG関連疾患 / IgG4 / CD248 / Thy-1 / fibrosis / PDGFRα / PDGFRβ |
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| Outline of Final Research Achievements |
To quantify the degree of fibrosis in various organs in IgG4 related disease, and to clarify the mechanism of the fibrosis in IgG4 related disease, this study was performed. Pericyte and myofibroblast cells were thought to be related to fibrosis of IgG4 related disease. Compared to non-IgG4 related disease, the degree of fibrosis was significantly higher. It was possible to quantify the degree of fibrosis in IgG4 related disease.
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