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Immunohistochemical analysis of Thy-1 and PDGF in IgG4-related disease

Research Project

Project/Area Number 25460465
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Human pathology
Research InstitutionKanazawa Medical University

Principal Investigator

KUROSE Nozomu  金沢医科大学, 医学部, 助教 (10319048)

Co-Investigator(Kenkyū-buntansha) Minato Hiroshi  金沢医科大学, 医学部, 教授 (10293367)
MASAKI Yasufumi  金沢医科大学, 医学部, 教授 (40238895)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
KeywordsIgG4関連疾患 / 線維化 / IgG関連疾患 / IgG4 / CD248 / Thy-1 / fibrosis / PDGFRα / PDGFRβ
Outline of Final Research Achievements

To quantify the degree of fibrosis in various organs in IgG4 related disease, and to clarify the mechanism of the fibrosis in IgG4 related disease, this study was performed. Pericyte and myofibroblast cells were thought to be related to fibrosis of IgG4 related disease. Compared to non-IgG4 related disease, the degree of fibrosis was significantly higher. It was possible to quantify the degree of fibrosis in IgG4 related disease.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (4 results)

  • [Journal Article] CD14(+) follicular dendritic cells in lymphoid follicles may play a role in the pathogenesis of IgG4-related disease.2015

    • Author(s)
      Satoh-Nakamura T, Kurose N, Kawanami T, Nakamura T, Iwao-Kawanami H, Nakajima A, Miki M, Sakai T, Fujita Y, Tanaka M, Fukushima T, Masaki Y
    • Journal Title

      Biomed Res.

      Volume: 36 Pages: 143-153

    • NAID

      130005065277

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Japanese variant of multicentirc cattleman's disease associated with serositis and thrombocytopenia-a report of two cases: Is TAFRO syndrome(Castleman-Kojima Disease) a distinct clinicopathological entity?2013

    • Author(s)
      Y.Masaki, A.Nakajima, H.Iwao, N.Kurose, T.Sato, T.Nakamura, M.Miki, T.Sakai, T.Kawanami, T.Sawaki, Y.Fujita, M.Tanaka, T.Fukushima, T.Okazaki, H.Umehara
    • Journal Title

      J. Clin. Exp. Hematop

      Volume: 53 Pages: 79-85

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Inflammatory monocytes may play a role of pathophysiology in IgG4-RD2014

    • Author(s)
      T.Satoh, T.Nakamura, N.Kurose, H.Iwao, A.Nakajima, M.Miki, T.Sakai, Y.Fujita, M.Tanaka, T.Fukushima, Y.Masaki
    • Organizer
      The 76th Annual Meeting of the Japanese Society of Hematology
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] 頭蓋内に限局したRosai-Dorfman病の1例2013

    • Author(s)
      土屋 直子, 道合万里子, 北楯優隆, 近藤 環, 的場宗孝, 利波久雄, 笹川泰生, 赤井卓也, 飯塚秀明, 黒瀬 望, 野島孝之
    • Organizer
      第49回日本医学放射線学会秋季大会
    • Place of Presentation
      名古屋国際会議場
    • Related Report
      2013 Research-status Report
  • [Presentation] 髄膜腫に類似した画像を呈した Rosai-Dorfman disease の1例2013

    • Author(s)
      赤井卓也, 笹川泰生, 立花 修, 飯塚秀明, 黒瀬 望
    • Organizer
      第31回日本脳腫瘍病理学会
    • Place of Presentation
      KFC Hall 国際ファッションセンター (東京都墨田区)
    • Related Report
      2013 Research-status Report
  • [Presentation] 多発肺結節影を伴ったIgG4関連疾患の一例2013

    • Author(s)
      森田 貴義, 正木 康史, 加藤 保宏, 川崎 貴裕, 小林 久美子, 黒瀬 望, 梅原 久範, 藤原 弘士
    • Organizer
      第57回日本リウマチ学会総会・学術集会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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