| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
In 1970s, it was reported that there was immunosuppressive factor(s) in serum of Candidiasis patients. In this study, the immunosuppressive effects of N-glycan purified from C. albicans surface mannoprotein. After injection of the N-glycan with lipopolysaccharide, up-regulation of immunosuppressive cytokine IL-10 in serum, but not IFN-g and TNF-a was observed. In a lethal model of sepsis, the N-glycan ameliorated survival rate of mice. These results suggest that N-glycan from C. albicans surface mannoprotein suppresses immune response thought augmentation of immunosuppressive IL-10 production.
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