Immune regulation though C-type lectin using microbial polysaccharides
Project/Area Number |
25460494
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Experimental pathology
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Research Institution | Kyoto University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
INABA Kayo 京都大学, 大学院生命科学研究科, 教授 (00115792)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | C. albicans / C型レクチン / 糖鎖 / IL-10 / 免疫制御 / 免疫抑制 / レクチン / 敗血症 |
Outline of Final Research Achievements |
In 1970s, it was reported that there was immunosuppressive factor(s) in serum of Candidiasis patients. In this study, the immunosuppressive effects of N-glycan purified from C. albicans surface mannoprotein. After injection of the N-glycan with lipopolysaccharide, up-regulation of immunosuppressive cytokine IL-10 in serum, but not IFN-g and TNF-a was observed. In a lethal model of sepsis, the N-glycan ameliorated survival rate of mice. These results suggest that N-glycan from C. albicans surface mannoprotein suppresses immune response thought augmentation of immunosuppressive IL-10 production.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] In vivo and in vitro analyses of a-galactosylceramide uptake by conventional dendritic cell subsets using its fluorescence-labeled derivative.2015
Author(s)
Ushida, M., Iyoda, T., Kanamori, M., Watarai, H., Takahara, K.* and Inaba, K.
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Journal Title
Immunol. Lett.
Volume: 168
Issue: 2
Pages: 300-5
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Amyloid β oligomers induce interleukin-1β production in primary microglia in a cathepsin B- and reactive oxygen species-dependent manner2015
Author(s)
Taneo, J., Adachi, T., Yoshida, A., Takeyasu, K.,Takahara, K. and Inaba, K.
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Journal Title
Biochem. Biophys. Res. Commun.
Volume: 458
Issue: 3
Pages: 561-567
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Functional evaluation of activation-dependent alterations in the sialoglycan composition of T cells.2014
Author(s)
Naito-Matsui Y, Takada S, Kano Y, Iyoda T, Sugai M, Shimizu A, Inaba K, Nitschke L, Tsubata T, Oka S, Kozutsumi Y, and Takematsu H.
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Journal Title
J. Biol. Chem.
Volume: 289
Issue: 3
Pages: 1564-1579
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Tracking and quantification of dendritic cell migration and antigen trafficking between the skin and lymph nodes.2014
Author(s)
Tomura M, Hata A, Matsuoka S, Shand FH, Nakanishi Y, Ikebuchi R, Ueha S, Tsutsui H, Inaba K, Matsushima K, Miyawaki A, Kabashima K, Watanabe T, Kanagawa O.
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Journal Title
Sci Rep.
Volume: 4
Issue: 1
Pages: 6030-6030
DOI
NAID
Related Report
Peer Reviewed / Open Access
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