| Project/Area Number |
25460523
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Parasitology (including sanitary zoology)
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
Osada Yoshio 産業医科大学, 医学部, 准教授 (80282515)
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| Co-Investigator(Renkei-kenkyūsha) |
KURODA ETSUSHI 大阪大学, 免疫学フロンティア研究センター, 准教授 (10299604)
YAMADA SOHSUKE 産業医科大学, 医学部, 講師 (90525453)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 免疫修飾 / 感染症 / 炎症 / 寄生虫 / 自己免疫疾患 / 糖尿病 / 関節炎 / サイトカイン / 蠕虫 / 住血吸虫 |
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| Outline of Final Research Achievements |
By comparison of multiple helminth species, we tried to find essential factors for anti-inflammatory properties of parasitic helminths. An intestinal nematode Heligmosomoides polygyrus (Hp) and Schistosoma mansoni (Sm) showed anti-diabetic effects on experimental type 1 diabetes in mice.These effects were observed not only in wild-type genetic background but also in dual genetic absence of STAT6 and IL-10. In such a genetic condition, non-typical M2-like macrophages were induced in the pancreatic lymph nodes and spleens and the cells might be involved in anti-diabetic effects of helminths. Sm is also known to suppress collagen-induced arthritis and in the current study we have found that the anti-arthritic effects of Sm were dependent on STAT6. The findings obtained in our research partially elucidated the anti-inflammatory effects of helminths and would contribute to development of lowly pathogenic helminth-based therapy on inflammatory diseases in the future.
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