• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Virulence mechanism of atopic dermatitis-related S. aureus

Research Project

Project/Area Number 25460533
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Bacteriology (including mycology)
Research InstitutionHiroshima University

Principal Investigator

Sugai Motoyuki  広島大学, 医歯薬保健学研究院(歯), 教授 (10201568)

Co-Investigator(Kenkyū-buntansha) HISATSUNE JUNZO  広島大学, 大学院医歯薬保健学研究院, 助教 (40513180)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
KeywordsS. aureus / アトピー性皮膚炎 / 黄色ブドウ球菌 / フィラグリン / 比較ゲノム / 菌固着
Outline of Final Research Achievements

Comparison of adherent bacterial number of AD-derived S. aureus and non AD-derived S. aureus to the skin of FKO mouse indicated AD-derived S. aureus adhered more to the skin. We established an expression plasmid carrying sarA P1 promoter and RBS sequence of sod gene hooked with gfp and transformed AD-deribed S. aureus. We also finished complete DNA sequencing of TF3378 (AD-derived) genome. Comparison with other finished sequences of S. aureus revealed some potential virulence-related genes specific to AD-derived S. aureus.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2016 2015 2014 2013 Other

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 8 results,  Open Access: 5 results,  Acknowledgement Compliant: 4 results) Presentation (3 results) Remarks (2 results)

  • [Journal Article] C55 bacteriocin produced by ETB-plasmid positive Staphylococcus aureus strains is a key factor for competition with S. aureus strains.2016

    • Author(s)
      Kawada-Matsuo M, Shammi F, Oogai Y, Nakamura N, Sugai M, Komatsuzawa H
    • Journal Title

      Microbiol Immunol.

      Volume: 60(3) Issue: 3 Pages: 139-147

    • DOI

      10.1111/1348-0421.12360

    • NAID

      40020779255

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Inhibitory effects of antibiofilm compound 1 against Staphylococcus aureus biofilms.2016

    • Author(s)
      Shrestha L, Kayama S, Sasaki M, Kato F, Hisatsune J, Tsuruda K, Koizumi K, Tatsukawa N, Yu L, Takeda K, Sugai M.
    • Journal Title

      Microbiology and Immunology

      Volume: 60 Issue: 3 Pages: 148-159

    • DOI

      10.1111/1348-0421.12359

    • NAID

      40020779260

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comprehensive Analysis of Systemically Disseminated ST8/non-USA300 type Community-acquired Methicillin-resistant <i>Staphylococcus aureus</i> Infection2014

    • Author(s)
      Hagiya H, Hisatsune J, Kojima T, Shiota S, Naito H, Hagioka S, Morimoto N, Otsuka F, Sugai M.
    • Journal Title

      Internal Medicine

      Volume: 53 Issue: 8 Pages: 907-912

    • DOI

      10.2169/internalmedicine.53.1746

    • NAID

      130003392776

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular epidemiology and identification of a Staphylococcus aureus clone causing food poisoning outbreaks in Japan.2014

    • Author(s)
      Sato'o Y, Omoe K, Naito I, Ono HK, Nakane A, Sugai M, Yamagishi N, Hu DL.
    • Journal Title

      Journal of clinical microbiology.

      Volume: 52 Issue: 7 Pages: 2637-2640

    • DOI

      10.1128/jcm.00661-14

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phospholipase C-related catalytically inactive protein participates in the autophagic elimination of Staphylococcus aureus infecting mouse embryonic fibroblasts.2014

    • Author(s)
      Harada-Hada K, Harada K, Kato F, Hisatsune J, Tanida I, Ogawa M, Asano S, Sugai M, Hirata M, Kanematsu T.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 5 Pages: e98285-e98285

    • DOI

      10.1371/journal.pone.0098285

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Application of moisturizer to neonates prevents development of atopic dermatitis.2014

    • Author(s)
      Horimukai K, Morita K, Narita M, Kondo M, Kitazawa H, Nozaki M, Shigematsu Y, Yoshida K, Niizeki H, Motomura K, Sago H, Takimoto T, Inoue E, Kamemura N, Kido H, Hisatsune J, Sugai M, Murota H, Katayama I, Sasaki T, Amagai M, Morita H, Matsuda A, Matsumoto K, Saito H, Ohya Y.
    • Journal Title

      The Journal of allergy and clinical immunology.

      Volume: 134 Issue: 4 Pages: 824-830

    • DOI

      10.1016/j.jaci.2014.07.060

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] A novel metallo-β-lactamase, IMP-34, in Klebsiella isolates with decreased resistance to imipenem.2013

    • Author(s)
      Shigemoto N, Kayama S, Kuwahara R, Hisatsune J, Kato F, Nishio H, Yamasaki K, Wada Y, Sueda T, Ohge H, Sugai M
    • Journal Title

      Diagnostic Microbiology and Infectious Disease

      Volume: 76 Issue: 1 Pages: 119-121

    • DOI

      10.1016/j.diagmicrobio.2013.02.030

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Identification and characterization of a novel aac(6’)-lag associated with the blaIMP-1-integron in a multidrug-resistant Pseudomonas aeruginosa2013

    • Author(s)
      Kobayashi K, Hayashi I, Kouda S, Kato F, Fujiwara T, Kayama S, Hirakawa H, Itaha H, Ohge H, Gotoh N, Usui T, Matsubara A, Sugai M
    • Journal Title

      PLoS One

      Volume: 8 Issue: 8 Pages: e70557-e70557

    • DOI

      10.1371/journal.pone.0070557

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 解説 黄色ブドウ球菌2013

    • Author(s)
      久恒順三, 達川伸行, 佐藤祐介, 加藤文紀, 鹿山鎭男, 菅井基行
    • Journal Title

      感染症内科

      Volume: 1 Pages: 275-285

    • Related Report
      2013 Research-status Report
  • [Presentation] おでき由来黄色ブドウ球菌が産生するヒアルロン酸分解酵素の解析2015

    • Author(s)
      窪田星子、達川伸行、久恒順三、金子淳、菅井基行
    • Organizer
      第88回日本細菌学会総会
    • Place of Presentation
      長良川国際会議場
    • Year and Date
      2015-03-26 – 2015-03-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 黄色ブドウ球菌の表層タンパク質 Skip の発現制御機構の解析2014

    • Author(s)
      達川伸行、久恒順三、林幾江、菅井基行
    • Organizer
      第67回日本細菌学会中国・四国支部総会
    • Place of Presentation
      徳島文理大学
    • Year and Date
      2014-10-04 – 2014-10-05
    • Related Report
      2014 Research-status Report
  • [Presentation] Impetigo/SSSS原性S. aureus pETBの薬剤耐性遺伝子獲得2014

    • Author(s)
      久恒順三, 桑原隆一, 加藤文紀, 菅井基行
    • Organizer
      第87回日本細菌学会総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Remarks] 広島大学大学院医歯薬保健学研究院細菌学教室

    • URL

      http://home.hiroshima-u.ac.jp/saikin/index.html

    • Related Report
      2014 Research-status Report
  • [Remarks] 広島大学大学院医歯薬保健学研究科医歯薬学専攻細菌学教室

    • URL

      http://home.hiroshima-u.ac.jp/saikin/index.html

    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi