| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
We studied on regulatory mechanisms of TBK1, which is activated by innate immune receptors and is known to play a critical role in DNA vaccines. We found different regulatory domains in C-terminal regions of TBK1 and IKKε, suggesting these kinases are potentially involved in distinct activation signals.
We also investigated novel TBK1 substrates and found out RGS (regulator of G protein signaling) proteins as novel TBK1 substrates. RGS proteins are phosphorylated along with activation of innate immune signaling, suggesting novel crosstalk between GPCRs (G protein coupled receptors) and innate immune receptors and signals activated by innate immune receptors may directly affected to GPCR pathways, such as chemokine receptor signaling..
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