| Project/Area Number |
25460602
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Toho University (2014-2015)
Tokyo University of Science (2013) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGAI Shigenori 東京医科歯科大学, 医歯(薬)学総合研究科, 准教授 (50348801)
WATANABE Toshio 奈良女子大学, 大学院人間文化研究科, 教授 (60201208)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | mTOR / サイトカイン / 樹状細胞 / ｍTORC1 / mTORC1 |
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| Outline of Final Research Achievements |
We have previously demonstrated that, in dendritic cells (DC), mTORC1 regulates the production of IL-12 as well as the T helper (Th) cell differentiation. In this study, we investigated the roles of mTORC1 in DC in T cell mediated-humoral immunity using DC-specific mTORC1 function-deleted (KO) mice. In KO mice, bovine serum albumin (BSA)-alum induced the production of antigen-specific IgG1 was decreased when compared with control mice. We also found the reduction of the proportion of Th2 cells in the spleen of immunized KO mice, suggesting that the mTORC1 in DC influences the antigen-specific antibody production through the regulation of Th cell differentiation.
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