HLA and classification of diabetes

Research Project

Project/Area Number	25460690
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Laboratory medicine
Research Institution	Ehime University
Principal Investigator	Onuma Hiroshi 愛媛大学, 医学(系)研究科(研究院), 准教授 (00294794)
Co-Investigator(Kenkyū-buntansha)	Takata Yasunori 愛媛大学, 医学部附属病院, 講師 (20432792) Osawa Haruhiko 愛媛大学, 大学院医学系研究科, 教授 (90294800) Kawamura Ryoichi 愛媛大学, 医学部附属病院, 講師 (90533092)
Project Period (FY)	2013-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	HLA / 糖尿病 / GAD抗体 / 分類
Outline of Final Research Achievements	The aim of this study is to perform new classification of diabetes by typing loci in HLA Class I and Class II(A, B, C, DR、DQ, DP) together with clinical information. We have collected 2700 samples of DNA and serum from diabetic patients and 2000 samples of those from control. HLA typing has been finished in 1200 DNA samples in diabetic patients and controls so far. GAD autoantibodies were determined in 2700 diabetic patients. GAD autoantibodies were detected in 10.2% in 1500 diabetic patients, which is higher than those in previous report in Japanese（Takeda H et al. Diabetes Care. 2002 25(6):995-1001）.