Identification of the significance of HMGB1 measurement in the lifestyle-related disease

• Project/Area Number: 25460693
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Kagoshima University
• Principal Investigator: Shimizu Toshiaki 鹿児島大学, 医歯学域医学系, 助教 (50468055)
• Co-Investigator(Kenkyū-buntansha): HASHIGUCHI Teruto 鹿児島大学, 医歯学域医学系, 教授 (70250917) ; TAKENOUCHI Kazunori 鹿児島大学, 医学部, 歯学部附属病院医員 (30646758) ; OYAMA Youko 鹿児島大学, 医学部, 歯学部附属病院特任助教 (20583470)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: HMGB1 / 3T3-L1 adipocyte / adipocytokine / adiponectin / obesity / innate / pro-inflammatory / new adipocytokine / adipocyte / obese / diabetes / metabolic syndrome

Outline of Final Research Achievements

HMGB1 might be an adipocytokine that acts as an innate pro-inflammatory mediator in white adipose tissue (WAT) of patients with obesity, which may be associated with insulin resistance and metabolic syndrome. Conversely, adiponectin protects against HMGB1-induced adipose tissue inflammation by partially suppressing HMGB1 release from adipocytes.
「HMGB1 is secreted by 3T3-L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin」 Obesity 2016「IN PRESS」

Research Products

• [Journal Article] HMGB1 is secreted by 3T3-L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin (2016)
  • Author(s): Toshiaki Shimizu, Munekazu Yamakuchi, Kamal K Biswas, Bibek Aryal, Shingo Yamada, Teruto Hashiguchi and Ikuro Maruyama
  • Journal Title: Obesity Volume: 印刷中
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] HMGB1は大型脂肪細胞から分泌される炎症性のアディポサイトカインでありインスリン抵抗性を誘導する (2015)
  • Author(s): 清水利昭, 山口宗一, 竹之内和則, 丸山 征郎、橋口照人
  • Organizer: 第55回日本臨床化学会年次学術集会
  • Place of Presentation: 大阪府吹田市 大阪大学 コンベンションセンター
  • Year and Date: 2015-10-30
• [Presentation] HMGB1 は炎症性のアディポサイトカインでインスリンシグナルを阻害する (2014)
  • Author(s): 清水利昭、山口宗一、 竹之内和則、橋口照人、丸山 征郎
  • Organizer: 第61回日本臨床検査医学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-11-22 – 2014-11-25
• [Presentation] アディポネクチンは新規炎症性アディポサイトカインHMGB1の分泌をJNKを介して阻害する
  • Author(s): 清水 トシアキ
  • Organizer: 第25回日本臨床化学会 第59回日本臨床検査医学会 九州地方会
  • Place of Presentation: 熊本