Identification of the significance of HMGB1 measurement in the lifestyle-related disease
| Project/Area Number |
25460693
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kagoshima University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HASHIGUCHI Teruto 鹿児島大学, 医歯学域医学系, 教授 (70250917)
TAKENOUCHI Kazunori 鹿児島大学, 医学部, 歯学部附属病院医員 (30646758)
OYAMA Youko 鹿児島大学, 医学部, 歯学部附属病院特任助教 (20583470)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | HMGB1 / 3T3-L1 adipocyte / adipocytokine / adiponectin / obesity / innate / pro-inflammatory / new adipocytokine / adipocyte / obese / diabetes / metabolic syndrome |
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| Outline of Final Research Achievements |
HMGB1 might be an adipocytokine that acts as an innate pro-inflammatory mediator in white adipose tissue (WAT) of patients with obesity, which may be associated with insulin resistance and metabolic syndrome. Conversely, adiponectin protects against HMGB1-induced adipose tissue inflammation by partially suppressing HMGB1 release from adipocytes.
「HMGB1 is secreted by 3T3-L1 adipocytes through JNK signaling and the secretion is partially inhibited by adiponectin」 Obesity 2016「IN PRESS」
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Report
(4 results)
Research Products
(4 results)
